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《Chinese Journal of Rehabilitation Medicine》 2005-01
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An experimental study in the treatment of spinal cord injury in rats with sodium β-Aescin

WANG Jinguang, ZHENG Qixin,GUO Xiaodong,et al.Author′s address Dept. of Orthopedics,Union Hospital,Tongji Medical College of Huazhong University of Science and Technology,Wuhan,430022  
Objective:To observe the changes of the spinal cord in injured SD rat treated with sodium β-Aescin and study the protection function of β-Aescin for the nerve.Method:23 SD rats were divided into three groups including control group,injured group,treated group.The spinal cords of the injured group were middle-degree injured with the improved Allen′s method. The change of nerve functions was observed. After executing the treated mice on the 12th day, the samples were examined with HE stain, immunocytochemistry technique(bcl-2,bax,fas) and TUNEL labelling. Result:The grade of nerve functions was improved distinctly in the treated group. The number of the positive cells for fas and bax in injured group was much more than that in the treated group(P0.05).The number of the positive cells for bcl-2 in injured group was much less than that in the treated group.Conclusion:Apoptosis was one important mode of neuron death after spinal cord injury. Sodium β-Aescin could advance distinctly the recovery of the nerve function and protect the nerve tissue.
【CateGory Index】: R96
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