Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Journal of Rehabilitation Medicine》 2009-08
Add to Favorite Get Latest Update

Effects of panaxadiol saponins and lycopene on abilities of learning and memory of senile mice with atlanto-axial joint instability

FAN Wenjing,ZHU Tongtong,GUO Yaxiong,et al. Department of Pathophysiology,School of Basic Medicine Sciences,Jilin University,Changchun,130021  
Objective:To compare the effects of panaxadiol saponins (PDS) with lycopene on the abilities of learning and memory in senile mice with learning and memory disorder by atlanto -axial joint instability. Method:The atlanto-axial joint instability model was established by injection with 30% lactic acid around the atlanto and axial vertebrae,30μl once weekly,three times totally. The changes of abilities of learning and memory in mice were observed with water-maze test. The activities of acetylcholine esterase (AchE) and the content of acetylcholine (Ach) in brain tissue were tested. Immunohistochemical staining with β -amyloid protein in mice hippocampus was demonstrated. Result:The model mice had longer swimming time and more errors (P 0.05) in water maze test compared with control group. PDS mice had significant short latency period and less errors in water-maze test (P 0.01),but the difference between PDS and lycopene groups was not obvious. Compared with model group,the activities of AchE reduced(P0.01),and the content of Ach increased in PDS and lycopene groups(P0.01). And in the two therapy groups,expressions of β-amyloid protein in mice hippocampus were less than that in model group. Conclusion:This study indicate that PDS and lycopene can improve the learning and memory abilities of mice and the metabolism of senile mice brain,which may be the mechanism of its protective effect to cerebral damage.
【CateGory Index】: R285
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【Citations】
Chinese Journal Full-text Database 4 Hits
1 LIN Gui-miao,ZHAO Hong-yan,FAN Wen-jing,TIAN Yuan-tong,SUN Lian-kun,ZHAO Li-juan~*(Department of Pathophysiology,School of Basic Medical Sciences,Jilin University,Changchun 130021,China);Effects of accumulation of lactic acid in atlanto-axial joint on abilities of learning and memory in senile mice[J];Journal of Jilin University(Medicine Edition);2006-06
2 JIN Qi-Huang, ZHANG Xue-Jun(Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences,Shanghai 200031, China);The relation between acetylcholinesterase (AChE) and β amyloid peptide (Aβ)[J];Chinese Bulletin of Life Sciences;2004-01
3 ZHANG Junyan,ZHANG Boai,ZHU Hongcan,et al. Dept. of Neurology,the First Affiliated Hospital of Zhengzhou University,Zhengzhou,450000;Effects of learning and memory training on spatial learning and memory deficits and its cholinergic mechanism in rats with global cerebral ischemia[J];Chinese Journal of Rehabilitation Medicine;2008-04
4 FAN Wen-jing, HE Jing-chun, CUI Wei, et al. The Department of Pathophysiology, School of Basic Medical Sciences, Jilin University, Changchun 130021, Jilin, China;Effect of Panaxadiol Saponins on Cerebral Functional Lesion Induced by Destabilization of Cervical Vertebra in Mice[J];Chinese Journal of Rehabilitation Theory and Practice;2007-04
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 Zhang Xiaojie1,2 Niu Yingcai1 Xing Guihua1 Lin Chunrong1 Li Xueyan1 Li Pengtao2 (1 Institute of Pharmaceutical Research,Qiqihaer College of Traditional Chinese Medicine,Qiqihaer,161042;2 Basic Medical College,Beijing University of Traditional Chinese Medicine,Beijing 100029);Effect of Tongluo Jiunao Oral Solution on Learning and Memory and the Expression of AChE in Hippocampus of AD Rats[J];China Journal of Traditional Chinese Medicine and Pharmacy;2007-06
2 YU Feng,XU Bo,SUN Li-yan,JI Liu(Key Laboratory of Adolescent Health Assessment and Exercise Intervention,Ministry of Education, College of Physical Education and Health,East China Normal University,Shanghai 200241 China);Alleviation Function of Treadmill Exercise on the Decrease of Learning and Memory and Its Relationship with ChAT and AchE in Hippocampus of D-galactose AD Rats[J];Journal of Beijing Sport University;2013-03
3 ZHU Tong-tong;LIN Gui-miao;FAN Wen-jing;LIU Guang-yao;ZHAO Li-hua;ZHAO Li-jing;ZHAO Li-juan;Department of Pathophysiology,Norman Bethune College of Medicine,Jilin University;Department of Orthopedics,China-Japan Union Hospital,Jinlin University;Urinary and Reproductive Center,School of Medical Science,Shenzhen University;Department of Basic Nursing,School of Nursing,Shanghai Traditional Chinese Medical University;;Expressions of Bcl-2 and Bax in hippocampal neurons of senile mice with cervical vertebral instability[J];Journal of Jilin University(Medicine Edition);2013-05
4 XIE Xun,YANG Meiyan,WU Bozhi,YAO Lihua,LI Chuhua(School of Life Science,Guangdong Provincial Key Lab of Biotechnology of Plant Development,South China Normal University,Guangzhou 510631,China);EFFECTS OF SCHISANDRA ON BEHAVIORAL LEARNING AND HIPPOCAMPAL AChE ACTIVITY IN OVARIECTOMIZED MICE[J];Journal of South China Normal University(Natural Science Edition);2010-03
5 Li Junhan1,Zhou Jin2,Huang Lei3(1.The Sports and Health Education Institute of Mianyang Normal University,Mianyang,621000,Sichuan,China;2.College of P.E,Nanchang Hangkong University,Nanchang,330063,Jiangxi,China;3.The Affiliated Sports Hospital of Chengdu Sports Institute,Chengdu,610041,Sichuan,China);The Biological Characteristic of Lycopene and Its Research in Sports Domain[J];Journal of Jilin Institute of Physical Education;2009-04
6 ;Effects of extract of Polygonatum odoratum on learning and memory function of aging mice induced by D-galactose[J];Chinese Journal of Ethnomedicine and Ethnopharmacy;2009-01
7 ZHANG Yue,HUANG Neng-hui,ZHANG Xiao-yi,LUO Jun (Department of Pharmachology,Guiyang Medical College, Guiyang 550004,China);Effects of ganoderma lucidum triterpenoids on learning and memory function of aging mice induced by D-galactose[J];Journal of Shanghai Jiaotong University(Medical Science);2007-08
8 XIA Chun-mei LI Na ZHANG Hai-yan ZHANG Zhou (Shanghai Institution of Materia Medica,Chinese Academy of Science,Shanghai 201203,China);Study of Immunohistochemistry in Brain for Different Transgenic Model Mice of Alzheimer's Disease[J];Journal of Shanghai Jiaotong University(Agricultural Science);2008-02
9 FAN Jin-qin(College of Physical Education,Shaoguan University,Shaoguan 512005,Guangdong,China);Analysis of lycopene on the human body and function of sport[J];Journal of Shaoguan University;2009-09
10 Jia Shoumei,Chen Liqun,Li Ping(Nursing College of Fudan University,Shanghai 200032 China);Investigation on the status quo of social function of patients with mild to moderate vascular dementia[J];Chinese Nursing Research;2011-13
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 LIU Xiu-ping(P.E.Teaching Unit,Weihai Branch School of Shandong University,Weihai 264209,Shandong China);Research on Effects of Lycopene on Human Free Radical Metablism after High Intensity Endurance Exercises[J];Journal of Beijing Sport University;2006-09
2 WANG Li-shi~1,ZHAO Li-juan~2,HE Jing-chun~2,LIN Guimiao~2,KOHMOTO Kaoru~1(1.Department of Molecular Biology,University of Tokyo,Tokyo 112-0000,Japan;2.Department of Pathophysiology,School of Basic Medical Sciences,Jilin University,Changchun 130021,China);Relationship between dementia and instability of cervical vertebral column in mice[J];Journal of Jilin University of (Medicine Edition);2005-05
3 LIN Gui-miao,ZHAO Hong-yan,FAN Wen-jing,TIAN Yuan-tong,SUN Lian-kun,ZHAO Li-juan~*(Department of Pathophysiology,School of Basic Medical Sciences,Jilin University,Changchun 130021,China);Effects of accumulation of lactic acid in atlanto-axial joint on abilities of learning and memory in senile mice[J];Journal of Jilin University(Medicine Edition);2006-06
4 MA Zhi-yun WANG Yong;EFFECT OF LYCOPENE ON THE ANTIOXIDOCTIVE ABILITY OF THE BODY AFTER THE FATIGUE TRAINING[J];Jiujiang Medical Journal;2005-04
5 GUO Sheng-long, ZHANG Qiao-jun, XIANG Li, et al.Department of Neurology, Second Hospital of Xi'an Jiao Tong University,Xi'an 710004, China;Study on neuropsychology, imageology and event-related potential in patients with vascular cognitive impairment[J];Journal of Clinical Neurology;2004-05
6 TIAN Li Ping~1,WANG Jin~1,XUE Lin~2(1.College of Biology,Shihezi University,Shihezi,Xinjiang?832003,China;2.Institute of Vegetable,Shihezi,Xinjiang?832003,China);The Research Advancement of Locopene[J];Agriculture & Technology;2006-01
7 WANG Ai-hua(BinZhou city people's hospital,ShanDong BinZhou 256610,China);The study on diet intervention in malnutrition in senile dementia[J];Journal of Qilu Nursing;2004-02
8 SUI Bo etc. (Shangdong Physical Education Institude,250063,China);Research on influence of endurance training on free radicals and SOD activity in serum[J];Journal of Shandong Physical Education Institute;2001-03
9 ZHANG Hui, ZHANG Chao-dong. Department of Neurology, the First Affiliated Hospital of China Medical University, Shenyang 110001, China;The effect of exercise training and its molecular mechanism on cognitive impairment in vascular dementia rat model[J];Chinese Journal of Contemporary Neurology and Neurosurgery;2006-06
10 Jian Zheng,Xin Yu Zhao,Feng Peng Li, Department of Neurology,Xinqiao Hospital, Third Military Medical University of Chinese PLA, Chongqing 400037, China;Relationship between changes of event-related potential P300 and cognitive function disorder in patients with vascular dementia[J];Chinese Journal of Clinical Rehabilitation;2004-28
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved