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《Acta Laboratorium Animalis Scientia Sinica》 2001-04
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Study on Main Morphological Characteristics, the Indices of Blood and the Level of Blood Grease of Human SR-AI Transgenic Mice Model

WANG Zongbao, WAN Laxiang, WU Duansheng, WU Mengjin, YANG Yongzong (Department of Laboratory Animal Science, Nanhua University, Hengyang 421001, China)  
Objective To make clear of the parameter of the morphology, viscera, blood and blood plasma grease about human SR AI transgenic mice in order to provide the available basis for the application of human SR AI transgenic mice model. Methods\ The lip length, the distance between the sockets, the body length, the tail length and the 12 visceral coefficients of human SR AI transgenic mice were measured by means of the vernier caliper and the electron balance and compared with those of C 57 BL/6J mice. Sysmex k 4500 type all blood automatic multi parameter amalytical instrument was used to detect the indices of blood. The content of the total cholesterol, triglyceride and the high density lipoprotein cholesterol in the blood plasma were measured by enzyme assay. Results\ The comparison of the external indices of morphology and visceral coefficients of human SR AI transgenic mice with those of C 57 BL/6J has no obvious significance. Mice have no obvious changes on indices of blood, and the change in blood grease protein also has on statistical significance ( P 0.05). The density of triglyceride increases a bit ( P 0 05). Conclusion\ The norm of external morphology, visceral coefficients and all the indices of blood on transgenic mice haven′t obvious changes. Authors suggest that human SR AI transgenic mice is suitable to apply to the study of atherosclerosis.
【Fund】: 国家自然科学基金项目 ( 3990 0 0 6 1);; 湖南省科技厅项目 ( 99JZY2 0 14 )
【CateGory Index】: Q954-33
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