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《Acta Laboratorium Animalis Scientia Sinica》 2013-01
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Establishment of a rat model of nephrosis induced by single tail vein injection of doxorubicin

ZHANG Yong1,ZHANG Bei1,NING Hua-ying1,GUO Yun-liang1,XING Guang-qun2,SHEN Wei1(1.Qingdao University Medical College;2.the Affiliated Hospital of Medical College, Qingdao University,Qingdao 266003,China)  
Objective To establish a rat model of doxorubicin-induced nephrotic syndrome and observe its dynamic development.Methods Twenty-six male Wistar rats were randomly divided into model group and control group.The model group received a single tail vein injection of doxorubicin 6.2 mg/kg body weight.The control group was injected with isotonic saline.12-hour urines were collected and checked for 12 weeks once a week.Finally the rats were sacrificed,the blood biochemical indexes were checked,and renal morphological changes were examined by light and electron microscopy.Results The urinary protein excretion in the model group was significantly increased(P0.01) at the 7th day and reached a peak at 5th week.The serum total protein and albumin were decreased,triglyceride,cholesterol and blood urea nitrogen were increased(all P0.05),while serum creatinine was not significantly changed(P=0.64).Minimal change disease was developed at the 5th week,and focal segmental glomerulosclerosis was observed at the 10th week.Conclusion A model of progressive nephritic syndrome in rats can be successfully established by a single tail vein injection of doxorubicin in a dose of 6.2 mg/kg body weight.
【Fund】: 国家自然科学基金项目(编号:81072754) 国家自然科学基金项目(编号:81072398);; 山东省科技发展计划(编号:2009GG10002044)
【CateGory Index】: R-332;R692
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