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《Acta Laboratorium Animalis Scientia Sinica》 2013-01
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Comparison of different behavioral tests in amyotrophic lateral sclerosis transgenic mice

YIN Jun-tao,ZHANG Hong-li,YAN Xin,WANG Ya-Fei,LIU Ya-ling.(The Second Hospital of Hebei Medical University,Shijiazhuang 050000,China)  
Objective To compare the application value of five tests in behavior assessment of amyotrophic lateral sclerosis transgenic mice.Methods This study included the model group(SOD1-G93A transgenic mice) and negative control group(littermate negative control).Behavioral changes were evaluated by five behavioral assessments(assessment of general condition,weighing,rotarod test,grip strength measurement and step length analysis).Results(1) Assessment of general condition: The general condition of the model group began to decline at day 89.The differences between negative control group and model group began to be significant on day 101,P=0.000.(2) Weighing: Weighing of the model group began to decline at week 15(day 105),and the differences between negative control group and model group became significant,P=0.026.(3) Rotarod test: The time of rotarod test began to decline at week 11(day 77).In week 13(day 91),the differences between negative control group and model group became significant,P=0.047.(4) Grip strength measurement: Grip strength for the hind limbs began to decline at week 10(day 70).In week 13(day 91),the differences between negative control group and model group became significant,P=0.000.(5) Step length analysis: Step length for hind limbs began to decline at week 14(day 98).In week 15(day 105),the differences between negative control group and model group became significant,P=0.000.Conclusion Grip strength measurement is better than the other four behavioral tests in the assessment of behaviors in SOD1-G93A transgenic mice.
【CateGory Index】: R-332
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1 AN Shu-ming,ZENG Qing-wen,XU Hao,LIU Ru-qing,CAO Xiao-hua(Key Laboratories of MOE and STCSM,Shanghai Institute of Brain Functional Genomics,East China Normal University,Shanghai 200062,China);Forebrain overexpression of αCaMKII disrupts behavioral flexibility[J];Journal of East China Normal University(Natural Science);2010-02
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