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《Acta Laboratorium Animalis Scientia Sinica》 2018-05
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The significance of a non-invasive measurement of lung function in mice

LI Shumin;ZHANG Min;WANG Peng;HONG Fan;WANG Chen;ZHANG Yue;GENG Zhenyang;YANG Xinyu;HE Xiaoxiao;SUN Ying;YANG Fang;School of Public Health, North China University of Science and Technology;Physiology Department,School of Basic Medical Sciences, North China University of Science and Technology;Research Center of Medical Experiment, North China University of Science and Technology;Pathology Department,School of Basic Medical Sciences, North China University of Science and Technology;  
Objective To provide a reference for studies of monitoring lung function in mice, this study was aimed to test the indexes of a non-invasive measurement of lung function in mice. Methods Lung function indexes of 460 C57 BL/6 mice were detected by whole-body plethysmography. The results were analyzed, and the range of reference values was determined by the percentile method. Results Normal ranges for the following measures were found: inspiration time was 64.7(55.30-82.60) ms, expiration time was 83.4(71.70-109.20) ms, Rpef was 0.21(0.16-0.28) ms, end-inspiratory pause was 2.19(1.96-3.76) ms, end-expiratory pause was 1.67(0.12-9.15) ms, tidal volume was 0.44(0.25-0.58) mL, enhanced pause was 1.29(0.91-2.00) ms, pause was 1.18(1.00-1.64) ms, expiratory flow-50 was 0.64(0.30-0.98) mL/s, relaxation time was 39.0(32.40-51.50) ms, peak inspiratory flow was 9.74(5.33-12.83) mL/s, peak expiratory flow was 9.86(5.12-13.47) mL/s, inspiratory frequency was 412(331-474) BPM, and minute volume was 174.4(86.69-235.04) mL. Conclusions The normal reference ranges from non-invasive lung monitoring in C57 BL/6 mice can be used as a reference for basic research on respiratory diseases.
【Fund】: 国家自然科学基金(81472953);; 河北省自然科学基金(H2016209170);; 华北理工大学大学生创新创业训练计划(X2018351)~~
【CateGory Index】: R56
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