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Rheumatoid Arthritis Model in Rat Induced by Type Ⅱ Collagen and Freund's Complete Adjuvant

Lin Hong, et al (Institute of Medicinal Plant Development Chinese Academy of Medical Sciences, Beijing))  
Objective Type Ⅱ collagen-induced arthritis(CⅡ-A)in rats has been compared with Freund's complete adjuvant arthritis (A-A) about legs size and pathological examination. Methods The legs size in CⅡ-A and A-A rats was measured by water exclusion. The legs of the arthritis rats were taken and cut section for pathological examination. Results The legs size and pathological section showed that some aspects including duration of arthritis, synovial membrane proliferation and cartilage damage were more significant in rats with CⅡ-A than those with A-A. Conclusions Comparing with A-A arthritis, CⅡ-A arthritis is a good animal model for rheumatoid arthritis.
【CateGory Index】: R593.22,R593.22
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