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Chemical Constituents of Pteris multifida and Their Inhibitory Effects on Growth of Rat Prostatic Epithelial Cells in vitro

QIN Bo 1,ZHU Da-Yuan 1*,JIANG Shan-Hao 1,XIANG Gui 2,LENG Ying 1,GU Zhi-Ping 1,WANG Yi-Qing 2,SHAO Xue-Feng 2 1 State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Shanghai Institute of Biological Sciences,Chinese Academy of Sciences,Shanghai 201203;2 Taicang People's Hospital,Taicang 215400,P.R.China  
AIM:To study the active chemical constituents of Pteris multifida against growth of rat prostatic epithelial cells(PECs).METHODS:Column chromatographies of macroporous resin D-1400,Sephadex LH-20,Rp-18,silica gel were used for the isolation of compounds,and spectroscopic techniques(NMR,IR,UV and MS)were used for the structural identification.The inhibitory activities of compounds on rat PECs growth were evaluated by MTT method under serum-free conditions with or without growth factors added to the culture medium.RESULTS:22 compounds were isolated from acetone and 20% ethanol extracts of the titled plant.Among them,luteolin,palmitic acid and apigenin 4'-O-α-L-rhamnopyranoside showed close effect against growth of rat PECs in vitro with epristeride.CONCLUSION:Pteroside P'(1)was identified to be a new C 14 sesquiterpene glycoside;luteolin,palmitic acid and apigenin 4'-O-α-L-rhamnopyranoside may be the main active components of Pteris multifida against benign prostatic hypertrophy.
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