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Chemical Constituents of Antihyperglycemic Active Fraction from Arctium lappa

XU Zhao-Hui,ZHAO Ai-Hua,GAO Xian-Fu,JIA Wei*School of Pharmacy,Shanghai Jiao Tong University,Shanghai,200240,China  
AIM:To investigate the bioactive compounds from Arctium lappa.METHODS:The compounds were obtained by various chromatographic methods including silica gel and sephadex LH-20 and their structures were elucidated on the basis of physical parameters and spectral data including IR,UV,NMR and MS.RESULT:Eight compounds were determined as matairesinol(Ⅰ),arctigenin(Ⅱ),lappaol A(Ⅲ),lappaol F(Ⅳ),lappaol C(Ⅴ),arctignan E(Ⅵ),arctiin(Ⅶ)and lappaol H(Ⅷ).CONCLUSION:All the compounds from the active fraction of Arctium lappa are lignans which might be associated with its hypoglycemic activities.
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