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《中国天然药物(英文版)》 2019-04
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Involvement of mitochondrial apoptotic pathway and MAPKs/NF-κB inflammatory pathway in the neuroprotective effect of atractylenolide Ⅲ in corticosterone-induced PC12 cells

GONG Wen-Xia;ZHOU Yu-Zhi;QIN Xue-Mei;DU Guan-Hua;Modern Research Center for Traditional Chinese Medicine, Shanxi University;Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College;  
Atractylenolide Ⅲ(ATL-Ⅲ), a sesquiterpene compound isolated from Rhizoma Atractylodis Macrocephalae, has revealed a number of pharmacological properties including anti-inflammatory, anti-cancer activity, and neuroprotective effect. This study aimed to evaluate the cytoprotective efficiency and potential mechanisms of ATL-Ⅲ on corticosterone injured rat phaeochromocytoma(PC12) cells. Our results demonstrate that ATL-Ⅲ increases cell viability and reduces the release of lactate dehydrogenase(LDH). The results suggest that ATL-Ⅲ protects PC12 cells from corticosterone-induced injury by inhibiting the intracellular Ca~(2+) overloading, inhibiting the mitochondrial apoptotic pathway and modulating the MAPK/NF-κB inflammatory pathways. These findings provide a novel insight into the molecular mechanism by which ATL-Ⅲ protected the PC12 cells against corticosterone-induced injury for the first time. Our results provide the evidence that ATL-Ⅲ may serve as a therapeutic agent in the treatment of depression.
【Fund】: supported by the National Nature Science Foundation of China(No.81673572);; the Applied basic research project of Shanxi Province(No.201601D021164);; the Innovation project of higher education institutions in Shanxi Province(No.2016120);; the Construction of the Science and Technology Basic Condition Platform of Shanxi Province(No.2014091022);; the Program of Science and Technology of Shanxi Province(No.20140313008-14)
【CateGory Index】: R285.5
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【Citations】
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1 GAO Yao;GAO Li;GAO Xiao-xia;ZHOU Yu-zhi;QIN Xue-mei;TIAN Jun-sheng;Modern Research Center for Traditional Chinese Medicine, Shanxi University;;An exploration in the action targets for antidepressant bioactive components of Xiaoyaosan based on network pharmacology[J];药学学报;2015-12
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