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《Chinese Journal of Microecology》 1993-01
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PRELIMINARY RESEARCH ON THE ANTITUMOUR EFFECT OF BIFIDOBACTERIUM aDOLESCENTIS ON THE MOUSE HEPTOCARCINOMA

Zhang Chao, et al Dept. of Pathology, Dalian Medical College, Dalian 116023  
The effect of Bifidobacterium adelescentis DM8504 strain on the growth of the transplantable mouse heptocarcinoma was studied. The experimental results showed that this living bacterial preparation injected by tail-vena or intraperitoneal ways could inhibit the growth of the transplantable mouse heptocarcinoma, whether it was injected before or after the inoculation of the tumour cells. This bacterial preparation injected by intraperitoneal way could enhance the macrophagocytic phagocytosis and the activity of the non-specific esterase of macrophagocytes. But in vitro it was not able to kill the mouse tumor cells directly. It is suggested that the antitumor effect of Bifidobacterium adolescentis was performed by activating the immunological system instead of effecting directly on the tumor cells
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