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《CHINESE JOURNAL OF MICROECOLOGY》 2000-01
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INFLUENCE OF BIFIDOBACTERIUM ON THE EXPRESSION OF INDUCIBLE NITRIC OXIDE SYNTHASE OF EXPERIMENTAL COLORECTAL CARCINOMA

Wang Lisheng, Pan Lingjia, Li Mingshong, et al. (PLA Institute for Digestive Medicine,Guangzhou,510515)  
Depending on the animal model of colorectal carcinoma transplantation tumors of nude mice,the expression of inducible nitric oxide synthase (iNOS) of colorectal carcinoma transplantation tumors was detected by employing immunohistochemical staining, when bifidobacteria adolescence were injected into nude mice peritoneally. The results showed that the expression rate、 expression density and the number of positive cells of iNOS oncoproteins of colorectal carcinoma transplantation tumors in the bifidobacterium injection group was significantly higher when compared with the tumor control group (P0 01). It was indicated that bifidobacteria adolescence could elevate the expression of iNOS might mediated the apoptosis of colorectal carcinoma transplantation tumors induced by bifidobacteria.
【CateGory Index】: R73-36
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