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《Chinese Journal of Microecology》 2006-01
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The expression of CD25 and negative effect of HCV-RNA in PBMC on treatment of α2b-IFN

WANG Jian,WANG Yu,JANG Shu-qing,XIANG Gui-ju(Department of Aetiology and Immumology,Medical College,Anhui University of Science and Technology,Huainan 232001,China)  
Objective To study the level of CD25 on surface of peripheral blood mononuclear cells(PBMC) and the effect of α2b-IFN on HCVRNA in PBMC and anti-HCV in serum.Methods Before and after treament,the level of CD25 of patients with chronic hepatitis C was detected by biotin-streptavidin(BSA) and the cases were treated with α2b-IFN(3 MU/d).The total course of the treatment of α2b-IFN was six months and per course of treatment was three months.Results Before and after treatment of α2b-IFN,the levels of CD25 in silence and inducement were(3.44±0.77%) and(33.62±3.95)%.The negative rates of HCV-RNA in the PBMC and HCV-RNA,anti-HCV in serum were 42.31%((11/26)),57.69%(15/26),65.38%(17/26),respectively.There was higher significantly difference between in treatment of α2b-IFN and controls(P0.01~P0.05).Conclusion CD25 could be induced by α2b-IFN during the treatment and better curative effect of α2b-IFN had been taken on the treatment of HCV-RNA in PBMC than that of the routine drugs.
【Fund】: 安徽省教育厅自然科学基金重点项目(编号:2003kj027zd
【CateGory Index】: R512.63
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