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《Chinese Journal of Microecology》 2008-01
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Building of Lactobacillus peptidoglycan specific immune modulating pathway by text-miming approach

SUN Jin1,CHANG Gui-fang,LE Guo-wei,SHI Yong-hui(1.State Key Laboratory of Food Science and Technology,Southern Yangtze University,Wuxi 214122,China)  
Objective To investigate the mechanism of Lactobacillus peptidoglycan modulating mammal immune response.Methods BALB/c mice were administrated(i.p.) with Lactobacillus peptidoglcyan once or three times.Peritoneal macrophages and splenic lymphocytes were isolated for gene expression analysis using genechip.Medscan were used to build a specific immune modulating pathway based on published relating scientific papers.Results The pathway implied that PGN induced a pro-inflammatory response pathway mediated by TLR2 and NF-κB.However,the response was under subtle modulation by peptidoglycan reorganization proteins L and NOD2.Conclusion Lactobacillus peptidoglycan induces a distinct immune response to maintain host immune homeostasis.
【Fund】: 教育部博士点基金项目(No20040295005);; 国家自然基金项目(No30671525)
【CateGory Index】: R392.1
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