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《Chinese Journal of Microecology》 2008-01
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Animal studies on enhancement of immune function by dietary probiotic supplementation of Lactobacillus acidophilus NCFM and Bifidobacterium lactis Bi-07

CAI Min1,CUI An2,HUANG Qiong1,HUANG Jian-kang1(1.Guangdong Center of Disease Control and Prevention,Guangzhou 510300,China;2.Dansico(China) Co.Ltd Guangzhou Office,Guangzhou 510630,China)  
Objective Tested and demonstrated the effect of two specific strains combination(Lb.acidophilus NCFM and Bifidobacterium lactis Bi-07) with certain dosage on immunity in animal(mice) studies.Methods Confer SPF-grade mice(Kuming species) certain and stable dosage probiotic supplement every day based on 0.25,0.50,1.50 g/kg BW respectively.After four weeks,carried out a series standard function experiments about immunity,including DTH test,Serum Hemdysin Test and the activity of NK cell Test etc.Result In the DTH test trigged by SRBC,the thickness' increasing from both middle and high dosage group was higher than that of control group;The antibody level of Serum Hemolysin Test from both middle and high dosage group was higher than that of control group;The result had significance for difference in compare with control group(P0.05).The activity of NK cell in high dosage group from the activity NK cell test had extremely obvious significance for difference in compare with control group(P0.01).Conclusion Dietary supplementation of these two specific strains with certain dosage can enhance the immunity of mice(enhancement of cellular immunity,body fluid immunity and the activity of NK cell etc).
【CateGory Index】: R371
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