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《Chinese Journal of Microecology》 2008-01
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Effects of probiotics on the expression of NF-κB and MCP-1 in liver following acute intrahepatic cholestasis in rats

HUANG Fang,HUANG Zhi-hua(Department of Pediatrics,the Affiliated Tongji Hospital of Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China)  
Objectives To investigate the effects of Bifico on the expression of nuclear transcription factor-kappa B(NF-κB) and monocyte chemoattractant protein-1(MCP-1) in liver tissue of acute intrahepatic cholestatic hepatic injury induced by alpha-haphtylisocyocyanate(ANIT),and further discuss the mechanism of probiotics to this models.Methods A total of 72 male SD rats were randomly divided into 3 groups:control group(n=8),intoxication group(n=32) and intervention group(n=32).The last two groups received a single intragastric administration of ANIT(100 mg/kg) to induce acute intrahepatic cholestasis.Bifico(4.2×108 kg-1day-1) was given to intervention group 3 days before administration.The expression of NF-κB and MCP-1 in the liver at 24,48,72,96 h after ANIT was given that were detected by RT-PCR and immunohistochemistry.The levels of the serum total bilirubin(TB) and alanine aminotransferase(ALT) were recorded at the same time.Results ALT and TB in intoxication and intervention groups were increased to top at 48 h after ANIT administration,while immunostaining for NF-κB and MCP-1 and RT-PCR for mRNA of MCP-1 showed the levels of their expression were strongest at the same time.But the above observation items of intoxication group were more significantly altered than those of intervention group.Conclusion Probiotics can decrease the expression of NF-κB and MCP-1,lower acute intrahepatic cholestatic hepatic injury.
【CateGory Index】: R371
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【Citations】
Chinese Journal Full-text Database 4 Hits
1 HU Yu-lian,HUANG Zhi-hua,WANG Xiao-dong,LIU Ping(Department of Pediatrics,Tongji Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology,Wuhan 430030,China);Effect of Probiotics on Migrating Myoelectric Complexes of α-Naphthylisothiocyanate Induced Cholestasis on Weaned Rats and Mechanism of Probiotics on Cholestasis[J];实用儿科临床杂志;2007-19
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【Co-citations】
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1 WANG Yin;LI Yuan-yuan;HAO Hai-bo;LIANG Hui;MA Ai-guo;Institute of Nutrition,Medical College of Qingdao University;;Protective effects of Lactobacillus casei on liver injury induced by rifampicin combined with isoniazid in rats[J];中国防痨杂志;2017-06
2 Ya GAO;Mingli ZHONG;Kefeng ZHANG;Guilin Medical University;;Effects of Qiweijingganling on Alcoholic Liver Injury of Rats[J];Medicinal Plant;2015-Z6
3 QIN Pei-lan;CHENG Ze-dong;Liaoning University of Traditional Chinese Medicine;;The thinking of discussion of acupuncture and moxibustion for regulating intestinal flora based on brain-gut axis theory[J];时珍国医国药;2015-11
4 Yang Jun;Li Shuixia;Chen Lina;Department of Neonatology,Dujiangyan People′s Hospital;Department of Pediatrics,West China Second University Hospital of Sichuan University;;Clinical analysis of risk factors of parenteral nutrition-associated cholestasis in very low birthweight infants[J];中华妇幼临床医学杂志(电子版);2015-05
5 PANG Xiaoli;WANG Zhaoxia;Department of Pediatric Gastroenterology,The First Hospital of Jilin University;;Relationship of intestinal microecology with infantile cholestatic liver disease[J];临床肝胆病杂志;2015-08
6 Wei Riming;Gao Ya;Zhong Mingli;Zhang Kefeng;Guilin Medical University;;Study on the protective effect of Dicliptera chinensis polysaccharide on rats liver induced by alcohol[J];中药药理与临床;2015-04
7 MA Ji;LIU Li;LI Jun;FAN Ying;ZI Hui;LU Jian;The Discipline of Prescriptions of Liaoning University of Traditional Chinese Medicine;;Effect of Baogan Granules on Acute Chemical Liver Injury in Mice with TNF-α and IL-1[J];中华中医药学刊;2015-06
8 Mingli ZHONG;Ya GAO;Yifei CHEN;Kefeng ZHANG;Guilin Medical University;;Protective Effects of Total Flavonoids in Polygonum perfoliatum L.on the Acute Liver Injury of Mice Induced by CCl_4 and Its Action Mechanism[J];Medicinal Plant;2015-Z2
9 GE Jin-hua;ZENG Xiang-quan;LIAN Yu-bao;The First Hospital of Sanming City to Affiliated Fujian Medical University;;The influence of probiotic to the intestinal flora in patients with chronic liver failure[J];中国微生态学杂志;2013-12
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