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《Chinese Journal of Microecology》 2008-01
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Study on drug-resistance of lung infection caused by Staphylococcus aureus and its carrying Panton-Valentine leukocidin genes

ZHANG Xue-qing1,CHEN Zeng-qiang1,HUANG Jin-wei2,YU Fang-you1(1.The First Affiliated Hospital of Wenzhou Medical College,Wenzhou 325000,China;2.The Central Hospital of Lishui City,Lishui 323000,China)  
Objective To analyze the drug-resistance of lung infection caused by Staphylococcus aureus and its carrying Panton-Valentine leukocidin genes.Methods The drug sensitivity results of 132 cases with lung infection by Staphylococcus aureus from January 2005 to January 2006 were investigated retrospective in local hospital.Staphylococcus aureus carrying Panton-Valentine leukocidin(PVL) genes were determined by multiplex PCR.Multilocus sequence typing(MLST) was used to determine the STs of the isolates.The genotypes of SCCmec were also determined by another multiplex PCR in the isolates of methicillin-resistant Staphylococcus aureus(MRSA).Results The drug-resistance of 132 strains Staphylococcus aureus was serious.The antibiotic drugs which had higher susceptibility ratio were vancomycin,nitrofurantoin and trimeth-sulfa et al.10 strains Staphylococcus aureus carrying Panton-Valentine leukocidin genes were all methicillin-resistant Staphylococcus aureus(MRSA),3 isolates of ST239-SCCⅢ,2 isolates of ST398-SCCmecⅢ,2 isolates of ST398-SCCmecⅣ,1 isolate of ST25-SCCmecⅢ,1 isolate of ST59-SCCmecⅠ and 1 isolate of ST88-SCCmec.Conclusion Staphylococcus aureus causing lung infections were multi-drug resistant to many kinds of antibiotics and its carrying Panton-Valentine leukocidin genes had certain ratio.
【Fund】: 温州市科技计划基金资助项目(NO20060277)
【CateGory Index】: R515
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【References】
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