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《Chinese Journal of Microecology》 2008-01
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The resistance monitoring inspection on Shigella with which children infected in Suzhou

TAO Yun-zhen,ZHU Li-juan,DING Yun-fang(The Clinical Laboratory,the Children Hosptial Affiliated to Soochow University,Suzhou 215003,China)  
Objective To investigate the resistance status of Shigella which infects children during 2000~2006 in Suzhou,learn the possible resistance trend and guide the reasonable clinical drug-usage.Method To collect 589 mutants of Shigella isolated from the clinical strains of our hospital during 2000~2006 and apply K-B to make a drug sensitivity test on Ampicil,Piperacillin,Cepoperazone,Ceftriaxone,Ciprofloxacin,SMZ+TMP,Imipenem.Result The resistance rates of the 470 mutants of Shigella flexneri during seven years were as follows:Ampicil:it was always above 90.0%;Piperacillin:it gradually rised from 22.6% to 63.2%;Cepoperazone:1.1%~ 56.1%;Ceftriaxone:2.2%~43.9%;Ciprofloxacin:it always keeped at 10.0 %;SMZ+TMP:it fluctuates between 70.0%~96.0%;all of these were sensitive to Imipenem.The resistance rates of the 119 mutants of Shigella sonnei were as follows:Ampicil:it gradually rised from 7.1% to 82.8%;Piperacillin:0~79.3%;Cepoperazone:0~55.2%;Ceftriaxone:0~51.7%;SMZ+TMP:it fluctuates between 62.5%~100.0%;all of these were sensitive to Ciprofloxacin and Imipenem.Conclusions Shigella flexneri with which local children were infected has a severe and high resistance to Ampicil and SMZ+TMP.In addition,its resistance rate towards Piperacillin and tert-cephalosporin presents an annually rising trend.Prior to 2004,the resistance rate of Shigella sonnei(except that towards SMZ+TMP) was far less than that of Shigella flexneri,however,its resistance rate towards Ampicil and tert-cephalosporin soared into a high level in 2005.Consequently,it was not so satisfactory on the resistance situation of Shigella with which children are infected in Suzhou and the treatment toward those children who suffer from shigellosis will be also in trouble.
【CateGory Index】: R446.5
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