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《Chinese Journal of Microecology》 2008-01
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Comparison the effect of different analgesic techniques on the perioperative serum IL-6,IL-8 and IL-10 in patients undergoing pelvic

XIU Yu-fang1,YANG Xue-feng,HUANG Dong-lin,XIAO Long(1.Department of Anesthesia,Gyneology and Obstetrics Hospital of Dalian,Dalian 116031,China)  
Objective To compare the effect of different analgesic techniques on the levels of serum cytokines after hysterectomy.Methods Sixty patients were randomly divided into three groups.GroupⅠreceived 50 mg pethidine when needed,GroupⅡreceived ropivacaine + fentanyl for PCEA,group Ⅲ received fentanyl for PCIA.The levels of serum interleukin-6,interleukin-8 and interleukin-10 were observed at six time points:before anesthesia,at 0.5,2,24,48 and 72 h after the end of surgery.Results The levels of serum IL-6,IL-8 and IL-10 increased significantly after operation,reached at peak values at 24 h(P0.05),and then gradually declined but still higher than the baseline values.The serum IL-6 and IL-10 were significantly lower at 2 and 24 h in groupⅡ and Ⅲ than those in groupⅠ(P0.05).Compared with group Ⅲ,the serum IL-10 was significantly lower at 24 h in groupⅡ(P0.05).Conclusion Epidural analgesia can reduce the level of serum interleukin-6,interleukin-8 and interleukin-10 and inflammatory response after hysterectomy more efficient than PCIA.
【CateGory Index】: R614
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