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《Chinese Journal of Microecology》 2008-06
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The study of antagonistic activity of Lactobacillus casei LC2W against Helicobacter pylori SS1 for adhesion to MKN-45 cells by mathematical models

ZHOU Fang-fang,WU Zheng-jun,WANG Yin-yu,GUO Ben-heng (The Technique Center of Bright Dairy & Food Co.,Ltd,Shanghai 200072,China)  
Objective To study the antagonistic activity of Lactobacillus casei LC2W against Helicobacter pylori SS1 for adhesion to MKN-45 cells and explicate the phenomena of bacterial adhesion and inhibition.Methods Gastric-cell line MKN-45 was cultured in vitro,plate counting was used to study the adhesive ability of the two strains;mathematical models based on a simple dissociation process were developed and the competition,exclusion and displacement between the two strains were compared according to the models.Results The equations obtained from the models allow the estimation of the maximal number of LC2W and Helicobacter pylori SS1 cells that could adhere to MKN-45 cells respectively;they also characterized the affinity of the bacteria to MKN-45 cells and the theoretical adhesion ratio of two bacteria present in a mixed suspension.The results showed that there were significant competition and elimination of Helicobacter pylori SS1 by LC2W,both of which were dependent on concentration of LC2W;the displacement of Helicobacter pylori SS1 by LC2W was insignificant or slow.Conclusions The mathematical models were suitable for simulating the adhesion and the antagonistic activity of LC2W against Helicobacter pylori SS1 for adhesion to MKN-45 cells,which meant the antagonistic activity was mainly attributed to the competitive space occupying between the two strains.
【CateGory Index】: R371;R735.2
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