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《Chinese Journal of Microecology》 2008-06
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Bacterial etiology and antimicrobial resistance patterns of community-acquired pneumonia in hospitalized children in Shenzhen

HOU Li-ying,ZHENG Yue-jie,DENG Ji-kui,ZHAO Rui-zhen (Shenzhen Children′s Hospital,Shenzhen 518026,China)  
Objective To investigate the bacterial etiology and antimicrobial resistance patterns of community-acquired pneumonia(CAP) in children.Methods Deep respiratory aspirate specimens from 1441 hospitalized children with CAP over a 1-year period were cultured,and the isolated bacterial strains were tested for antimicrobial susceptibility.Results 761 strains were isolated from 722 patients(50.1%) of which,170(22.3%) were Klebsiella pneumoniae,130(17.1%) were Escherichia coli,89(11.7%) were Streptococcus pneumoniae,63(8.3%) were Staphylococcus aureus,60(7.9%) were Hemophilus influenzae and Hemophilus parainfluenzae.The detection rates of methicillin-resistant S.aureus(MRSA) and penicillin-nonsusceptible S.pneumoniae(PISP+PRSP) were 15.9% and 84.3%,respectively.The prevalence of ESBLs-producing strains in Klebsiella pneumoniae,Escherichia coli,Serratia spp and Enterobacter cloacae were 31.2%,46.2%,94.8% and 16.8% respectively.The resistance rates of Hemophilus influenzae and Hemophilus parainfluenzae to ampicilin were 40% and 36% respectively.The resistance rates of Pseudomonas aeruginosa and Acinetobacter baumannii to imipenem were 10.7% and 13.2% respectively.Conclusions In isolated strains from Shenzhen children hospitalized with CAP,gram-negative bacilli were more common than gram-positive cocci.The isolated bacteria have high levels of resistance to commonly prescribed antibiotics.
【Fund】: 深圳市医学重点学科建设项目(2005C03)资助
【CateGory Index】: R725.6;R446.5
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