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《Chinese Journal of Microecology》 2008-06
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Clinical use of probiotic lactobacillus preparation to prevent diarrhoea associated with antibiotics in intensive care unit

YAN Jie,XU Hong-yang,YANG Ting,LIANG Feng-ming,ZHOU Wei-gui,YAN Zheng(Department of Critical Care Medicine,Wuxi People′s Hospital,Wuxi 214002,China)  
Objective To assess the preventive efficacy of a probiotic agent containing lactobacillus on antibiotic-associated diarrhoea in ICU.Methods 181 patients in intensive care unit(ICU) were divided into the prevention group and the control group in random.The prevention group was given a probiotic agent containing Labctobacillus casei,L.bulharicus and Streptococcus thermophilus,on the basis of conventional therapy.Incidence of antibiotic-associated diarrhoea was observed in the two groups.Results 8/90(8.89%) of the prevention group developed antibiotic-associated diarrhoea compared with 23/91(25.27%) in the control group(P0.05).The absolute risk reduction was 16.38%(8.89% to 25.27%).Conclusions Consumption of a probiotic agent containing Labctobacillus casei,L bulharicus and Streptococcus thermophilus can reduce the incidence of antibiotic associated diarrhoea.This has the potential to decrease morbidity,healthcare costs and mortality if used routinely in patients in ICU.
【CateGory Index】: R595.3
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