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《Chinese Journal of Microecology》 2009-01
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The study on the variance of HCV E protein gene and significance of the variance

WANG Guo-qiang1,XING Shan-xia2(1.Department of Clinical Laboratory of the First Affiliated Hospital of Xinxiang Medical University,Weihui 453100,China;2.The Infectious Disease Hospital of Xinxiang City,Xinxiang 453000,China)  
Objective To analyze the variation of E protein gene of HCV from different sub-types and identical hypotypes and the significance of the variance.Method The entire gene sequence of HCV collected from the public database of GenBank was used as the material,and the homology of these sequences was analyzed with the CLustalw2 software.Result The E protein gene variations among different hypotypes were up to 70.5%(E1 protein gene)and 59.8%(E2 protein gene);E2 protein genes of different hypotypes had two high variation areas,while that of the same hypotype had only one high variation area;the variation rates of E protein gene from identical hypotypes were 11.8%~16.8%(E1 protein gene)and 18.4~29.9%(E2 protein gene).Conclusion Based on the smaller gene variation of the E protein of identical hypotypes,the antigen epitope of hypotype to develop multi-valent polypeptide vaccine or multi-gene mixed vaccine,which could have a protective immune function to infections caused by many kinds of different hypotype viruses.
【CateGory Index】: R373
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1 XU Jin-ping 1,2, YE Lin-bai2, MENG Xiao-lin2, SHE Ying-long2, WU Zheng-hui2 (1. College of Life Science and Techology, Huazhong Agricultural University, Wuhan 430070, Hubei,China; 2. Institute of Virology, Wuhan University, Wuhan 430072, Hubei,China);Study on Immunogenicity of Hepatitis C Virus Envelope Protein E1 in Mice and Rabbits[J];Wuhan University Journal(Natural Science Edition);2002-06
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