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《Chinese Journal of Microecology》 2009-10
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Effect of Bifidobacterium on the jejunal mucosal secretion of sIgA in SD Rat

HAO Ya-ning,WANG Rong-rong,MA Yong-ping,LI Jiang,LI Shi-bin,LIU Ge-li(Molecular Medicine & Cancer Research Center of Chongqing Medical University,Chongqing 400016,China)  
Objective To research the immunologic adjuvant effect of bifidobacterium.Method SD rats were randomly divided into three groups and immunized by ovalbumin(OVA)alone,bifidobacterium ﹢OVA and PBS alone,respectively.After each group was immunized,about 3 cm jejunum was collected to systematically analyze the location of sIgA with immunohistochemistry technology and Qwin image manipulation system,and study the effect of injecting ovalbumin and bifidoacterium,when injected sitmultaneously,on positive sIgA cell secretion in the jejunum of the immune SD rats in different time.Result Specific secreted antibody IgA was detected in the jejunum of the immune rats.The titer of sIgA antibodies of the bifidobacterium ﹢OVA group were found to be significantly greater(P 0.05)than those of the other two groups immunized with single vaccine.Conclusion Bifidobacterium could effectively induce the function of immunologic adjuvant by intestinal mucosal immune.
【Fund】: 国家自然科学基金资助项目(30200244)
【CateGory Index】: R392.1
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