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《Chinese Journal of Microecology》 2009-10
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Influnce of intestinal flora in mice for Gatifloxacin

CHEN Yan 1,LUO Yu 2(1.Clinical Laboratory Department,the Second People Hospital of Zhengzhou 450006,China;2.Department of Microbiology and Immunology,Henan Academy of Medical and Pharmaceutical Sciences,Zhengzhou 450052,China)  
Objective To understand the influnce of intestinal flora in mice for normal dose medication and abnormal dose medication with gatifloxacin.Method 24 KM mice used in this experiment were randomly divided into 3 groups,each of 8 mice.Then the mice of control group received saline and the mice in other two experimental groups received gatifloxacin normal dose and half of normal dose medication respectively for 7 days.Feces samples of the mice were taken by aseptic manipulation and cultured for assessment of amount of enterobacteriaceae,enterococcus,bacteroides,bifidobacterium and lactobacillus growing in the intestine.Result Gatifloxacin by intragastrical irrigation for 7 day.Compared to previous medicines,the result of antibiotic susceptibility had no obvious changes.Enterobacteriaceae kept sensitive to CIP,LEV,GAT,AM,CRO,AMK and NOR respectively.Enterococcus kept sensitive to AM,LEV,VA and GAT respectively,different sensitivity to NOR,CIP and CRO.Two medications pattern lead to the amount of enterobacteriaceae decrease notability(P ﹤0.05)and the amount of enterococcus increased somewhat(P ﹥0.05).While the amount of bacteroides,bifidobacterium and lactobacillus floras had no obvious changes.Conclusion Use of gatifloxacin for 7 day has no obvious change of intestinal flora with two medications pattern(except for enterobacteriaceae).Gatifloxacin is not easy to come into being drug resistance for short-term.That kill enterobacteriaceae is greater than to anaerobe.
【CateGory Index】: R965
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