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《Chinese Journal of Microecology》 2012-01
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Effect of isomalto oligosaccharide on intestinal mucosal immunity of aging model mice

WANG Chun-min1,MA Shu-xia1,TONG Li-bo2,HAN Gui-hua2,CUI Gang1,OU Qin3(1.Department of Microbiology,Jiamusi University,Jiamusi 154007,China;2.The First Affiliated Hospital of Jiamusi University,Jiamusi 154002,China;3.Department of Biochemistry,Jiamusi University,Jiamusi 154007,China)  
Objective To explore the modulating function of isomalto oligosaccharide on intestinal mucosal immunity of aging model mice and its possible mechanisms.Method 48 Kunming mice were randomly divided into 4 group: young control group,aging model group,IMO group and IMOLCM group.After the aging models were made by injection of D-galactose,the IMO group was given IMO while IMOLCM group was given IMO and lincomycin.Each group were killed after 30 days.We detected the quantity of intestinal flora by the method of quantitative detection;the level of sIgA of intestinal mucous membrane by the method of radioimmunity;the expression of the IgA+ plasma cell in mice′s intestinal mucous membrane by the immunohistochemical method.Result(1) Dysbacteria could be observed in aging mice;The level of sIgA of intestinal mucous membrane,IgA+ plasma cell in aging model group were lower than the young control group′s;(2) Dysbacteria had improwed in IMO group;The level of sIgA of intestinal mucous membrane,the number of IgA+ plasma cell in IMO group were higher than the aging model group′s(P0.05);(3) Dysbacteria could be observed again in IMOLCM group;The level of sIgA of intestinal mucous membrane,the number of IgA+ plasma cell in IMOLCM group were lower than the IMO group′s(P0.05).Conclusion(1) IMO can improve dysbacteriosis of aging model mice and enhance the function of intestinal mucosal immunity.(2) That IMO can improve immunity may come true mainly by increasing the number of probiotics.
【Fund】: 黑龙江省卫生厅科研项目(2010-481)
【CateGory Index】: R-332
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