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《Chinese Journal of Microecology》 2012-01
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Comparison of Andrographolide and other active ingredients of Chinese herbal medicine in regard to Staphylococcus epidermidis biofilm permeability

GUAN Yan1,WANG Ning1,WANG Chang-zhong1,LIU Zhi-fang1,ZHANG Jiu-yun1,SHI Jing-jin2(1.Anhui University of Traditional Chinese Medicine,Hefei 230038,China;2.Bengbu Medical College,Bengbu 233030,China)  
Objective To compare the permeability of andrographolide,emodin and berberine through Staphylococcus epidermidis biofilms,and provide a basis for treating infections caused by S.epidermidis.Method In vitro models of S.epidermidis biofilm(SE-BF) and penetration of biofilm(PB) were established,and the penetrating ratios of andrographolide,emodin and berberine were analyzed.Result The penetrating ratios of andrographolide and emodin for 36h were 82.89% and 88.00%,respectively,while that of berberine was lower than the other two.Conclusion These active ingredients of Chinese herbal medicine have a strong S.epidermidis biofilm permeability.
【Fund】: 安徽省教育厅自然科学研究重点项目(KJ2010A214)
【CateGory Index】: R285
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