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《Chinese Journal of Microecology》 2012-01
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Establishment of mice model of vaginal Candidias albican dysbacteriosis

LIN Gang1,LU Shao-yan1,ZONG Su-jin1,LI Liang2,DU Ji-mei1,FANG Zhou-xi1,LIU Jia-ming2,YAO Wei1(1.School of Medical Laboratory Science;2.School of Environmental Science and Public Health,Wenzhou Medical College,Wenzhou 325035,China)  
Objective To establish the mice model of vaginal Candidias albican dysbacteriosis.Method The mice were given intravaginally 30 μL of metronidazole suspension(12.5 mg/mL) for five days,then inoculated intra-vaginally with 30 μL of Candida albicans suspension(1×108 CFU/mL) for five days.After treatment the vaginal fluids were quantified by culture,and vaginal tissue was observed by electron microscope.Result The amounts of Candidias albican increased significantly and the amounts of Lactobacillus decreased significantly in the model group(P0.01).There were typical symptoms such as vaginal swell,clumpish secretion and congestive vaginal mucous membrane in the model group.Conclusion The persistent vaginal colonization with Candidias albican induced by administration of metronidazole was established in mice.
【Fund】: 温州市科技局计划项目(Y20080123)
【CateGory Index】: R711.3
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Chinese Journal Full-text Database 1 Hits
1 YANG Bao-li,YANG Jing-yun,YANG Bao-liang (Hongqi Hospital of Mudanjiang Medical Collete,Mudanjiang 157001,China);Study on the adjustment to Candida albicans vaginal mcro-ecosystem with Lactobacillus[J];Chinese Journal of Microecology;2005-04
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