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《Chinese Journal of Microecology》 2012-01
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Establishment of mice model of vaginal Candidias albican dysbacteriosis

LIN Gang1,LU Shao-yan1,ZONG Su-jin1,LI Liang2,DU Ji-mei1,FANG Zhou-xi1,LIU Jia-ming2,YAO Wei1(1.School of Medical Laboratory Science;2.School of Environmental Science and Public Health,Wenzhou Medical College,Wenzhou 325035,China)  
Objective To establish the mice model of vaginal Candidias albican dysbacteriosis.Method The mice were given intravaginally 30 μL of metronidazole suspension(12.5 mg/mL) for five days,then inoculated intra-vaginally with 30 μL of Candida albicans suspension(1×108 CFU/mL) for five days.After treatment the vaginal fluids were quantified by culture,and vaginal tissue was observed by electron microscope.Result The amounts of Candidias albican increased significantly and the amounts of Lactobacillus decreased significantly in the model group(P0.01).There were typical symptoms such as vaginal swell,clumpish secretion and congestive vaginal mucous membrane in the model group.Conclusion The persistent vaginal colonization with Candidias albican induced by administration of metronidazole was established in mice.
【Fund】: 温州市科技局计划项目(Y20080123)
【CateGory Index】: R711.3
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【Citations】
Chinese Journal Full-text Database 1 Hits
1 YANG Bao-li,YANG Jing-yun,YANG Bao-liang (Hongqi Hospital of Mudanjiang Medical Collete,Mudanjiang 157001,China);Study on the adjustment to Candida albicans vaginal mcro-ecosystem with Lactobacillus[J];中国微生态学杂志;2005-04
【Co-citations】
Chinese Journal Full-text Database 4 Hits
1 LIN Gang1,LI Liang2,LU Shao-yan1,ZONG Su-jin1,FANG Zhou-xi1,LIU Jia-ming2,YAO Wei1(1.School of Medical Laboratory Science,Wenzhou Medical College,Wenzhou 325035,China;2.School of Environmental Science and Public Health,Wenzhou Medical College,Wenzhou 325035,China);Screening of antibiotic-resistant Lactobacillus and its adjustment to vaginal Candida albicans dysbacteriosis[J];中国微生态学杂志;2012-02
2 LIN Gang1,LU Shao-yan1,ZONG Su-jin1,LI Liang2,DU Ji-mei1,FANG Zhou-xi1,LIU Jia-ming2,YAO Wei1(1.School of Medical Laboratory Science;2.School of Environmental Science and Public Health,Wenzhou Medical College,Wenzhou 325035,China);Establishment of mice model of vaginal Candidias albican dysbacteriosis[J];中国微生态学杂志;2012-01
3 ;阴道菌群失衡与复发性假丝酵母菌性阴道炎相关性分析和防治[J];中外妇儿健康;2011-08
4 LIU Jia-ming1,LIN Gang2,HONG Na1,JI Peng1,ZHUO Ji-xuan2,ZHENG Te2,YAO Wei2 (1.The Public Health Medicine of Wenzhou Medical College,Wenzhou 325035,China;2.The Experiment Education Center of Biology of Wenzhou Medical College,Wenzhou 325035,China.);A study on vaginal dysbacteriosis caused by antibiotics and the adjustment by Lactobacillus[J];中国微生态学杂志;2009-11
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