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《Chinese Journal of Microecology》 2012-01
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Gut microbial ecosystem and obesity

SHEN Ding-shu(Taizhou Hospital,Taizhou 317000,China)  
The human gut is a lush microbial ecosystem containing about 100 trillion microorganisms.The microbiota may contain approximately 500 to 1000 species;the microbiome contains 100-fold more genes than the entire human genome does.The germ-free mice had 42% less total body fat than their normal counterparts,even though they consumed 29% more food.Furthermore,transplantation of cecal microbiota from normal mice into the germ-free mice(a process known as conventionalization) resulted in a 57% increase in total body fat and insulin resistance without any increase in food consumption or changes in energy expenditure.These findings suggest that the presence of gut microbiota significantly increases the energy harvest from diet and promotes fat deposition,and triggering systemic inflammation.Future treatments for obesity may involve modulation of gut microbiota using probiotics or prebiotics.We summarize some of the studies that have advanced the understanding of the microbiome and its effects on metabolism,obesity and health.
【CateGory Index】: R589.2
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