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《Chinese Journal of Microecology》 2012-04
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Analysis of cinnamon oil composition and the anti-cancer effect of cinnamaldehyde

CHEN Li-ping1,ZHANG Hui-ping1,CHEN Guang2,WANG Shu-xiang2,LIU Yue-xia2,TAN Hong2,LIU Lei2(1.Jiamusi Center Hospital,Jiamusi 154002,China;2.College of Basic Medical Sciences,Jiamusi University,Jiamusi 154007,China)  
Objective To investigate the anti-tumor effect of cinnamaldehyde.Method Steam distillation method was used to extract the cinnamon oil and gas chromatography-mass spectrometry was used to analyze its compounds.MTT assay was used to test the inhibitory effect of cinnamaldehyde at different concentrations on different types of tumor cell lines in vitro.IC50 was calculated.Result The yielding rate of cinnamon oil was 1.96%.10 different compounds were analyzed,with cinnamaldehyde as the main ingredients which accounted for 93.94% of the total distillate peak area;After cinnamaldehyde treatment,the proliferation of human cervical cancer cell line HeLa,lung cancer cell line A549 and human hepatoma cell line HepG2 was blocked in a dose-dependent manner.The IC50 values of cinnamaldehyde for human cervical cancer cell line HeLa,lung cancer cell line A549 and human hepatoma cell line HepG2 were 0.20 mg/ml,0.36 mg/ml and 0.73 mg/mL respectively by MTT method.Conclusion Cinnamaldehyde has anti-tumor activity in vitro.
【CateGory Index】: R285.5
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