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《Chinese Journal of Microecology》 2012-04
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Meta-analysis: the effect of probiotics supplement on standard triple therapy for Helicobacter pylori eradication

LI Sheng,DING Bai-jing,YANG Yong(Department of Gastroenterology,the Second People′s Hospital of Wuhu Affiliated to Wannan Medical College,Wuhu 241000,China)  
Objective To systematically evaluate the effect of the probiotics and standard triple therapy on the eradication of H.pylori and the side-effects of anti-H.pylori treatment.Method Frequently used electronic databases were searched for all the randomized placebo controlled clinical trials of standard triple therapies with and/or without combination of probiotics for treatment of H.pylori.The summary odds ratio(OR) of H.pylori eradication rate and side-effects incidence of these trials was meta-analyzed.The publication bias was tested by funnel plot.Result Fifteen randomized clinical trials were included in the analysis.Pooled H.pylori eradication rate was 79.7%(95% CI: 77.1%~82.3%) and 69.5%(95% CI: 66.5%~72.5%) with and without combination of probiotics,respectively;the summary OR was 1.75(95% CI: 1.40~2.18);the total occurrence of side-effects was 27.7%(95% CI: 24.5%~30.9%) and 53.0%(95%CI: 49.4%~56.6%) in groups with and without probiotics,respectively;the summary OR was 0.35(95% CI: 0.21~0.60).Conclusion Probiotics supplement is effective in increasing the eradication rate during standard triple therapy for H.pylori eradication.Furthermore,probiotics show a positive impact on H.pylori therapy related side-effects.
【CateGory Index】: R57
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