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《Chinese Journal of Microecology》 2012-09
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Drug-resistance and infectious characteristics of Streptococcus pneumonia and Haemophilus influenzae in children

CHU Li-juan,LIU Lan,XIE Wei,JING Chun-mei,FU Xiao-hong(Clinical Laboratory Center of Children's Hospital Affiliated with Chongqing Medical University,Chongqing 400014,China)  
Objective To study the distribution and antibiotic resistance of Streptococcus pneumonia(SP) and Haemophilus influenzae(Hi) from pediatric respiratory tract infection,and the interaction between drug-resistant strains and antibiotics,so as to guide rational antibacterial therapy.Methods SP and Hi were isolated from sputum,pharyngeal swab or bronchoalveolar lavage fluid specimens of pediatric respiratory tract infection during 2009 to 2010.Hi was identified by V and X factors′ requirement test,and β-lactamase was tested by Cephalosporins tanner thiaphenol method.SP was identified by optochin and bile lysozyme.The drug sensitivity of all strains were determined by Kirby-Bauer method.Results 495 strains of SP and 515 strains of Hi were isolated,most of which were from children under 3 years old.The highest isolation rate were found in Pneumology Department.The resistance rates of SP to erythrocin,tetracycline,Azithromycin and cotrimoxazole were 98.4%,66.1%,98% and 81.6%,respectively.Only 9.5% of SP were sensitive to penicillin.42.7% of β-lactamase producing strains were found in Hi.The resistance rates of Hi to chloramphenicol,cotrimoxazole,ampicillin and azithromycin were 22.1%,21.6%,36.7% and 62.7%,respectively.Compared to penicillin-sensitive SP and β-lactams negative Hi,the resistant SP and positive Hi were more prone to be resistant to chloramphenicol,cotrimoxazole and tetracycline.Conclusion SP and Hi usually appear in children under 3 years old in Pneumology Department.The drug-resistances of both bacteria are severe.Penicillin-resistant and β-lactams positive strains are prone to induce other antibiotic resistance.Rational use of antibiotics and surveillance should be taken into account.
【Fund】: 重庆市卫生局科教资助项目(渝卫科教[2008]45号2008-2-151)
【CateGory Index】: R446.5
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【References】
Chinese Journal Full-text Database 6 Hits
1 JIN Liang;LI Da;WANG Yongyan;Department of Clinical Laboratory ,The First Hospital of Qinhuangdao;;Analysis of Staphylococcus Aureus and Streptococcus Pneumoniae Distribution and Drug Resistance Trend of 2012-2016[J];临床输血与检验;2018-01
2 JIN Liang;ZHAO Jianhong;SHI Dongyan;LI Zhirong;FENG Junhua;WEN Hainan;ZUO Jianghua;SU Wei;XING Huan;Department of Laboratory Medicine, Qinhuangdao First Hospital;;Antimicrobial resistance of Streptococcus pneumoniae strains isolated from 53 hospitals across Hebei in 2015[J];中国感染与化疗杂志;2017-06
3 Peng Yi;Shu Chang;Fu Zhou;Chengdu Women & Children's Central Hospital;Children's Hospital of Chongqing Medical University;;Changes of Pathogen and Antimicrobial Resistance of 1,613 Children with Community Acquired Pneumonia[J];儿科药学杂志;2016-10
4 TAO Qi;LI Yong-xiang;Clinical Laboratory,Jiaxing Maternity and Child Health Care Hospital;;Analysis of epidemiological characteristics and drug resistance of H. influenzae in preschool children[J];中国卫生检验杂志;2016-14
5 XIAO Hang;WU Xiang-lin;YAO Wei;LU Xiao-juan;CHEN Jun-ling;WANG Guang-lei;LI Ru-kai;Shiyan People's Hospital of Baoan District;Guangming New District People's Hospital;Songgang People's Hospital of Baoan District;;Antimicrobial resistance analysis in Haemophilus influenzae strains isolated from children with respiratory tract infection[J];热带医学杂志;2014-12
6 WANG Yong;BU Jingsong;Department of Laboratory Medicine,Shangyu People's Hospital;;Proteomic analysis of penicillin-resistant streptococcus pneumoniae strain[J];浙江医学;2014-22
【Citations】
Chinese Journal Full-text Database 6 Hits
1 HUANG Lu1,JI Wei1,DING Yun-fang2,TAO Yun-zhen2,WU Jun-hua1,LUO Ya-li1(The Children's Hospital Affiliatedto Soochow University,Suzhou 215003,Jiangsu,China);Children with acute lower respiratory tract infection associated with drug-resistant Streptococcus pneumonia[J];临床儿科杂志;2010-06
2 DENG Qiu-lian*, DENG Li, XIE Yong-qiang, HUANG Yong, ZHONG Hua-min,ZHOU Zhen-wen,HUANG Xu-qiang,SHEN Xu-zhuang.*Guangzhou Chirdren’s Hospital, Guangzhou 510120, China;Study on serotype and the resistance of haemophilus influenzae from children with respiratory tract infection in Guangzhou.[J];中国实用儿科杂志;2009-05
3 ZHANG Tao1,ZHAO Gen-ming1,TAO Yun-zhen2,CHEN Rong1,ZHU Li-juan2,LIN Yu-zun1,DING Yun-fang2,HAO Chuang-li3(1Key Laboratory of Public Health Safety,Ministry of Education-Department of Epidemiology,School of Public Health,Fudan University,,Shanghai 200032,China;2Department of Clinical Laboratory,3Department of Respiratory,Children's Hospital,Suzhou University,Suzhou 215003,Jiangsu Province,China);Antibiotics susceptibility of clinical Streptococcus pneumoniae isolates in Suzhou,China[J];复旦学报(医学版);2008-03
4 YANG Jin-hong,YANG Hai-wei,LI Xiang-yang,WANG Hui-yan(Yuying Pediatric Hospital,Wenzhou Medical College,Wenzhou,Zhejiang 325027,China);Antimicrobial Resistance among Clinical Streptococcus pneumoniae Isolates from Children[J];中华医院感染学杂志;2007-12
5 WANG Hui *,YU Yun song,LIU Yong,LI Hua yin,HU Bi jie,SUN Zi yong,CHEN Min jun. *Bacteriological Laboratory, Peking Union Medical College Hospital,Chinese Academy of Medical Sciences,Beijing 100730, China;Resistance surveillance of common community respiratory pathogens isolated in China,2002-2003[J];中华结核和呼吸杂志;2004-03
6 Zhang hong,lu quan,li wanhua,kong jing,wang chun.shanghai children's hospital,shanghai200040;Study on dru-resistance of haemophilus influenzae in children with acute reSpiratory tract infections in shanghai city[J];临床儿科杂志;2003-01
【Co-citations】
Chinese Journal Full-text Database 7 Hits
1 YU Huina;FU Qiang;YAN Xia;ZHOU Yun;QU Yue;WANG Ting;ZHOU Yizheng;YANG Yan;Department of Pediatrics, Jingzhou Central Hospital;Department of Clinical Laboratory, Jingzhou Central Hospital;;A retrospective study on the epidemic characteristics of Streptococcus pneumoniae in Jingzhou area[J];临床与病理杂志;2018-03
2 Yuanquan LIAO;Department of Clinical Laboratory, Anhui Jingxian People's Hospital;;Infectious pneumonia etiology laboratory diagnosis: Streptococcus pneumoniae detection technology progress[J];临床检验杂志(电子版);2018-01
3 XU Jie-ling;Department of Clinical Laboratory, Huizhou Huidong County People's Hospital;;Drug sensitivity analysis of clinical isolates of Streptococcus pneumoniae[J];中国实用医药;2017-34
4 WANG Jian;ZHAO Lan-hua;LI Ran-hui;Emergency Department,First Affiliated Hospital,University of South China;Institute of Pathogen Biology,Medical College,University of South China;;Prokaryotic expression and purification of the Tpx protein from Streptococcus pneumoniae[J];中国病原生物学杂志;2017-06
5 LIU Guangzhong;NI Wei;YANG Liu;XIAO Mingzhong;Traditional Chinese Medicine Hospital in Hubei;;Detection and antimicrobial resistance of Streptococcus pneumoniae isolated from children with respiratory tract in a traditional chinese medicine hospital of Hubei provincial[J];临床医药实践;2017-02
6 Wen Bei;He Gang;Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital;;A Randomized,Double-blind and Double-dummy Clinical Trial of CefditorenPivoxil in Treatment of Children with Acute Bacterial Sinusitis[J];四川医学;2016-11
7 XUE Yanying;CUI Na;LI Junfang;LI Zhimei;The Traditional Chinese Medicine Hospital of Dacheng town Hebei Langfang;The Traditional Chinese Medicine Hospital of Langfang City Hebei;Maternal and Child Health Care Hospital of Dacheng Hebei;;The Experience of Activating Blood Circulation Theory for the Treatment of CAP Pulmonary Consolidation[J];中医药临床杂志;2016-05
【Co-references】
Chinese Journal Full-text Database 8 Hits
1 SHAN Huan;JIN Kai-Ling;YE Jin-Ming;ZHANG Pei-Wei;LIN Kai;CHEN Wei-Guo;CHU Wen-Jie;XIAO Zhen;Zhejiang Hospital;;Epidemiological analysis on methicillin-resistant Staphylococcus aureus incidence from 2010 to 2015 by time series model[J];中华医院感染学杂志;2016-23
2 WANG Xian;ZHEN Bing-Hong;LUO Xiao-Qin;Department of Pediatrics,Central Hospital of Bao'an District;;Analysis of risk factors and bacterial drug resistance in children with pneumonia caused by multi-drug resistant Streptococcus pneumoniae[J];中国妇幼保健;2016-23
3 WANG Fang;XIONG Yan;CHEN Zhi;ZHAO De-feng;JIANG Yuan-shan;ZHOU Jun-bo;ZHAO Ying;Department of Pathogen Biology,Wuhan Centers for Disease Control and Prevention;;Antibiotic resistance and MLST analysis of Streptococcus pneumoniae isolates from healthy infants in Wuhan[J];公共卫生与预防医学;2016-03
4 SHENG Yi-quan;XIA Shou-hui;ZHOU Yun;SHEN Juan;ZHU Jian-ming;HUANG Zhi-mi;The 98 th Hospital of PLA;;Distribution and drug resistance of Staphylococcus aureus in 2011-2014[J];中华医院感染学杂志;2016-01
5 SHU Lin-Hua;XU Jiang-Jiang;WANG Shu;ZHONG Hai-Qin;DONG Xiao-Yan;JIANG Kun;ZHANG Hui-Yan;XIONG Qin;WANG Chao;SUN Ting;SUN Chao;LU Quan;Department of Respiratory Medicine, Shanghai Children's Hospital,Shanghai Jiao Tong University;;Distribution of pathogenic microorganisms and its relationship with clinical features in children with community-acquired pneumonia[J];中国当代儿科杂志;2015-10
6 HU Fupin;ZHU Demei;WANG Fu;JIANG Xiaofei;XU Yingchun;ZHANG Xiaojiang;ZHANG Zhaoxia;JI Ping;XIE Yi;KANG Mei;WANG Chuanqing;WANG Aimin;XU Yuanhong;SHEN Jilu;SUN Ziyong;CHEN Zhongju;NI Yuxing;SUN Jingyong;CHU Yunzhuo;TIAN Sufei;HU Zhidong;LI Jin;YU Yunsong;LIN Jie;SHAN Bin;DU Yan;HAN Yanqiu;GUO Sufang;WEI Lianhua;WU Ling;ZHANG Hong;KONG Jing;HU Yunjian;AI Xiaoman;ZHUO Chao;SU Danhong;Institute of Antibiotics,Huashan Hospital,Fudan University;;CHINET 2014 surveillance of bacterial resistance in China[J];中国感染与化疗杂志;2015-05
7 XIE Chengbin;WANG Pinjia;WU Yulu;YAN Yuan;YI Juan;SU Zhe;Department of Laboratory Medicine,Sichuan Provincial Hospital of Women and Children;;Antimicrobial resistance and ftsI genotyping of Haemophilus influenzae isolates from respiratory tract in children[J];中国感染与化疗杂志;2015-04
8 XIANG Xiang-yuan;LI Min;Laboratory of the Second people Hospital of Three Gorges University,Yichang City' second people hospital;;Patients in hospital with Staphylococcus aureus resistance monitoring report of 2009-2013[J];中国处方药;2015-05
【Secondary References】
Chinese Journal Full-text Database 7 Hits
1 ZHAO Ying;WANG Rong-shan;ZHU Wen-zhu;JIN Hong-xing;JIN Xiu-ping;FAN Xing-li;Clinical Laboratory,Keqiao District Hospital of Traditional Chinese Medicine;;Establishment and clinical application of double polymerase chain reaction for capsulate and non-capsulate Haemophilus influenzae[J];中国卫生检验杂志;2017-21
2 YUAN Yi;CHEN Wenbi;LIU Jinbo;FU Weiping;Department of Pathogenic Biology, College of Basic Medical Sciences, Southwest Medical University;;Distribution and antimicrobial resistance of the bacterial strains isolated from lower respiratory tract in children[J];中国感染与化疗杂志;2017-05
3 Ni Wei;Liu Guangzhong;Yang Liu;Hubei Provincial Hospital of TCM;;Monitoring and nursing countermeasures of Haemophilus influenzae in children with respiratory tract infection in Hubei Provincial Hospital of TCM[J];护理研究;2017-21
4 YE Man;WEN Xiao-jun;Seventh Affiliated Hospital of Guangxi Medical College;;Pathogenic Bacteria of Community Acquired Pneumonia and their Drug Resistanceamong the Children from 2013 to 2015 in Wuzhou[J];现代预防医学;2017-10
5 LIU Junfen;HA Da;Inner Mongolia University;;Application of PCT and CRP in the treatment of children lower respiratory tract infection caused by different pathogens[J];包头医学院学报;2017-05
6 WU Min;XU Hao;Clinical Laboratory,the Second Hospital of Jinhua;;Analysis of the risk factors and drug resistance status of the elderly community acquired pneumonia caused by H. influenzae[J];中国卫生检验杂志;2016-24
7 Ding Zhengxiang;Wang Yichang;Xu Xiaohong;Sanmen Ppeople's Hospital of Zhejiang Province;;Biological Typing and Drug Resistance of the Haemophilus Influenzae of Children with Respiratory Infections in Sanmen County from 2013 to 2014[J];儿科药学杂志;2016-04
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 WANG Gang1,LIU En-mei1,CHEN Yuan1,XIONG Wan1,LIU Zuo-yi1,HUANG Ying1,KUANG Feng-wu1,LIU Lan1,SHEN Xu-zhuang2,YANG Yong-hong2(1. Children's Hospital Affiliated to Chongqing Medical University,Chongqing 400014;2.Beijing Children's Hospital Affiliated to Capital Medical University,Beijing 100045,China);Survey on the antibiotic use and antibiotic resistance during 2005 to 2006[J];临床儿科杂志;2008-07
2 LU Quan(Shanghai Children's Hospital Affiliated to Shanghai Jiaotong University,Shanghai 200040,China);Respiratory tract infections:the changing nature of and strategy against bacterial pathogens[J];临床儿科杂志;2008-06
3 ZHANG Jing*,SUN Zi-yong,MA Yue,LI Jing-yun,JIN Shao-hong(*China-Japan Friendship Hospital,Beijing 100029,China);Resistance and Serotype of 152 Strains of Streptococcus pneumoniae[J];中华医院感染学杂志;2007-04
4 WANG Ling ,LU Quan, WANG Chuan-qing , DENG Qiu-lian, LIU Lan, ZHEN Jing-hui, ZHANG Hong, WANG Yi , HUANG Yong, CHEN Yuan, YANG Yong-hong, SHEN Xu-zhuang (Children's Hospital of Capital University of Medical Sciences, BeijingA 100045;Children's Hospital of Jiaotong University, Shanghai 200040;Children 's Hospital of Fudan University, Shanghai 200032;Guangzhou Children's Hospital, Guangzhou 510120; Children's Hospital Affiliated to Chongqing University, Chongqing 400014);Susceptibility of Gram-positive bacteria to antimicrobial drugs among pediatric patients in China: an analysis of hospital data from Beijing, Shanghai, Guangzhou and Chongqing 2000-2004[J];中国循证儿科杂志;2006-02
5 LIU You-ning~*,CHEN Min-jun,ZHAO Tie-mei,WANG Hui,WANG Rui,LIU Qing-feng,CAI Bai-qiang,CAO Bin,SUN Tie-ying,HU Yun-jian,XIU Qing-yu,ZHOU Xin,DING Xing,YANG Lan,ZHUO Jian-sheng,TANG Ying-chun,ZHANG Kou-xing,LIANG De-rong,L Xiao-ju,LI Sheng-qi,LIU Yong,YU Yun-song,WEI Ze-qing,YING Ke-jing,ZHAO Feng,CHEN Ping,HOU Xiao-na.~*Department of Respiratory Medicine,General Hospital of PLA,Beijing 100853,China;A multicentre study on the pathogenic agents in 665 adult patients with community-acquired pneumonia in cities of China[J];中华结核和呼吸杂志;2006-01
6 ZHENG Ya-fen,CHENG Xiao-jing,HAN Xiao-ya,SONG Haiying,WEI Zi-wen(Changzhou Women and Children Health Care Hospital,Changzhou 213003,China);Erythromycin Resistance and Resistance Related Genes Investigation of Isolated Streptococcus pneumoniae from Newborns[J];中华医院感染学杂志;2005-10
7 YAO Kai-hu~*, LU Quan, DENG Li, YU Sang-jie, ZHANG Hong, DENG Qiu-lian, SHEN Xu-zhuang, YANG Yong-hong. ~*Beijing Children′s Hospital, Capital University of Medical Sciences, Beijing 100045, China;Carrier rate of Streptococcus pneumoniae and susceptibility thereof to antimicrobial drugs among children in China: a surveillance study in Beijing, Shanghai, and Guangzhou 2000—2002[J];中华医学杂志;2005-28
8 ZHANG Hong, LU Quan, LI Wan-hua, WANG Chun. (Shanghai Children’s Hospital, Shanghai 200040, China);Study on the resistance of Haemophilus influenzae from children with respiratory tract infection[J];中国抗感染化疗杂志;2005-03
9 DING Yun-fang*, MI Zu-huang, ZHANG Jian-hua, TAO Yun-zhen,QIN Ling. *The Affiliated Children’s Hospital of Suzhou University, Suzhou 215003, China;Study on the molecule epidemiological between resistances of 7 genes interrelated 4 antibiotic to isolated Streptococcus pneumoniae in children[J];中华流行病学杂志;2005-06
10 HUA Chun -zhen, YU Hui-min, SHANG Shi-qiang, LI Jian-ping, CHEN Zhi-min, WANG Jie-h ua. Department of Central Laboratory, Children′s Hospital Affiliated to Medica l College, Zhejiang University , Hangzhou 310003, China;Serotypes and antibiotics-resistance patterns of 247 strains of Haemophilus Influenzae isolated from children in Hangzhou[J];中华儿科杂志;2004-11
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