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《Chinese Journal of Microecology》 2012-09
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Huangguaxiang combined with cisplatin for treatment of H22 liver cancer in mice

REN Ji-qiu1,LIU Zhen-ping2,MA Shu-xia1,WANG Chun-min1,YANG Chun-jia1,AN Hong-xin3(1.Department of Microbiology,Basic Medical College,Jiamusi University,Jiamusi 154007,China; 2.General Surgery Department of the First Affiliated Hospital of Jiamusi University,Jiamusi 154007,China; 3.Logistic Management Department of Jiamusi University,Jiamusi 154007,China)  
Objective To observe the inhibitory effect of Huangguaxiang(Matteucciastruthiopteris(L.)Todaro) combined with cisplatin on the growth of transplanted H22 liver cancer tumors in mice.Methods 40 model mice transplanted with H22 liver cancer cells were randomly divided into four groups,which were respectively injected with physiological saline(Control group),Huangguaxiang(Huangguaxiang group),cisplatin(Cisplatin group),and Huangguaxiang plus cisplatin(Combination group).The adverse reaction and life quality of mice were observed.After 19 days,all the mice were sacrificed to measure the weight of subcutaneous tumors and calculate the tumor inhibition rate.Results The average weight of H22 liver cancer tumor in Huangguaxiang group was(1.26±0.19)g,obviously lower than that of the control group(1.89±0.56)g(P0.01).The tumor weight of Combination group was(0.57±0.42)g,significantly lower than those of the Huangguaxiang group(P0.01) and Cisplatin group(P0.01).The tumor inhibition rate in combination group was 69.8%,obviously higher than those of the Huangguaxiang group(χ2=16.9875,P0.01) and cisplatin group(χ2=5.0602,P0.05).Toxic side reaction in combination group was obviously lower than in the cisplatin group;life quality in combination group was better than in cisplatin group;Intestinal flora adjustment was observed in both Huangguaxiang and the combination group,with the growth of beneficial bacteria(lactic acid bacteria and bifidobacteria) promoted and that of E.coli inhibited,which had a significant difference compared with the control group(P0.01).Conclusion The combination of Huangguaxiang and cisplatin can synergistically inhibit the growth of H22 liver tumor,reduce toxic side reaction caused by cisplatin,and improve the life quality of mice.
【Fund】: 佳木斯大学科研课题项目资助(S2011-002)
【CateGory Index】: R735.7
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