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《Chinese Journal of Microecology》 2012-09
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Effects of portulaca oleracea polysaccharide (POP) on intestinal flora,serum TNF-α,HGF and content of blood endotoxin in mice with fulminant hepatic failure

FENG Lan1,WANG Feng-ying2,MA Shu-xia3,DAI Li-juan1(1.The First Affiliated Hospital′s Infection and Internal Medicine of Jiamusi University,Jiamusi 154002,China;2.Faculty of Science of Jiamusi University,Jiamusi 154007,China;3.Basic Medical College of Jiamusi University,Jiamusi 154007,China)  
Objective To study the influence of portulaca oleracea polysaccharide(POP) on intestinal flora,serum TNF-α,HGF and content of blood endotoxin in the mice with fulminant hepatic failure,and explore the adjustment mechanism of traditional Chinese medical micro-ecological modulator to fulminant hepatic failure.Methods Mice models of fulminant hepatic failure were created by intraperitoneal injection of D-galactosamine and lipopolysaccharide,and then treated with POP.Normal control groups and negative control groups were set up.Mice were put to death after 14 days of administration for detection of serum TNF-α,HGF and content of endotoxin in blood.Results After intraperitoneal injection of D-galactosamine and lipopolysaccharide,mice intestinal flora got disordered,and serum TNF-α,HGF and content of endotoxin in blood increased.After 14 days of POP treatment,the serum TNF-α and content of blood endotoxin decreased,and HGF increased.ConclusionPOP can adjust the intestinal flora disorder,reduce the production of enterogenous endotoxin fulminant,lower the expression of plasma inflammatory cell factor and increase HGF to lessen the damage to liver caused by enterogenous endotoxinemia,and improve the liver function of mice with fulminant hepatic failure.
【CateGory Index】: R285.5
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