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《Chinese Journal of Microecology》 2012-09
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The genetype of carbapenemase produced by imipenem-and/or meropenem-resistant Acinetobacter baumannii isolates

WEI Yan-yan1,XIONG Zi-zhong2,ZOU Gui-zhou1(1.Department of Infectious Diseases,the Second and First Affiliated Hospitals,Anhui Medical University,Hefei 230022,China;2.The First Affiliafed Hospital,Anhui Medical University,Hefei 230000,China)  
Objective To investigate the genetype of carbapenemase produced by imipenem-resistant and/or meropenem-resistant Acinetobacter baumannii strains clinical isolated.Methods A total of 29 strains of imipenem-resistant and/or meropenem-resistant Acinetobacter baumannii were screened by PCR with primer pairs designed to detect genes encoding OXA-23,24,51,58 and VIM,IMP enzymes,respectively.Results In the 29 carbapenemase producers,OXA-24 and IMP were the most common,each accounting for 51.7%(15/29).The positive strains of OXA-24+IMP,OXA-24+OXA-51+IMP,VIM,OXA-24+OXA-58+IMP,OXA-23+OXA-24+IMP,OXA-23+IMP,OXA-51+OXA-24,OXA-24 and IMP were 5,4,4,2,2,1,1,1 and 1 strain,respectively.Conclusion OXA-24 and IMP are the main genotypes of carbapenemase in imipenem-resistant and/or meropenem-resistant Acinetobacter baumannii.
【Fund】: 安徽省自然科学基金(050430804);; 安徽省优秀青年科技基金(08040106815)
【CateGory Index】: R440
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