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《Chinese Journal of Microecology》 2012-09
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The genetype of carbapenemase produced by imipenem-and/or meropenem-resistant Acinetobacter baumannii isolates

WEI Yan-yan1,XIONG Zi-zhong2,ZOU Gui-zhou1(1.Department of Infectious Diseases,the Second and First Affiliated Hospitals,Anhui Medical University,Hefei 230022,China;2.The First Affiliafed Hospital,Anhui Medical University,Hefei 230000,China)  
Objective To investigate the genetype of carbapenemase produced by imipenem-resistant and/or meropenem-resistant Acinetobacter baumannii strains clinical isolated.Methods A total of 29 strains of imipenem-resistant and/or meropenem-resistant Acinetobacter baumannii were screened by PCR with primer pairs designed to detect genes encoding OXA-23,24,51,58 and VIM,IMP enzymes,respectively.Results In the 29 carbapenemase producers,OXA-24 and IMP were the most common,each accounting for 51.7%(15/29).The positive strains of OXA-24+IMP,OXA-24+OXA-51+IMP,VIM,OXA-24+OXA-58+IMP,OXA-23+OXA-24+IMP,OXA-23+IMP,OXA-51+OXA-24,OXA-24 and IMP were 5,4,4,2,2,1,1,1 and 1 strain,respectively.Conclusion OXA-24 and IMP are the main genotypes of carbapenemase in imipenem-resistant and/or meropenem-resistant Acinetobacter baumannii.
【Fund】: 安徽省自然科学基金(050430804);; 安徽省优秀青年科技基金(08040106815)
【CateGory Index】: R440
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【Citations】
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【Co-citations】
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1 Chen Ping,Liu Ding,Wang Hao,Wang Zheng,Cheng Yao (Center for Infection Control,Research Institute of Surgery,Daping Hospital,Third Military Medical University/Chongqing Center for Hospital Infection Control,Chongqing 400042,China);A survey of point prevalence rate of nosocomial infection in Chongqing area[J];Chongqing Medicine;2011-36
2 SUN Shu-mei,WANG Yin-yin,YAO Cui-jun,LI Hai-lan,YU Fang,ZHANG Ya-li,ZHOU Hao,WANG Neng-ping Department of Nosocomial Infection Control,Nanfang Hospital,Southern Medical University,Guangzhou 510515,China;Clinical characteristics and therapy of pan-drug resistant Acinetobacter baumannii infection[J];Journal of Southern Medical University;2010-10
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8 SHI Teng-fei1,CHEN Hui-yu2,HONG Guo-lin1(1.Department of Clinical Laboratory,Fuzhou,No.2 Hospital,Fuzhou,Fujian 350007,China;2.Department of Clinical Laboratory,Maternal and Child Health Hospital of Fujian Province,Fuzhou 350000,China);Clinical distribution and antimicrobial resistance analysis of Acinetobacter baumannii isolates in a hospital during 2007-2010[J];Laboratory Medicine and Clinic;2011-18
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