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《Chinese Journal of Microecology》 2014-01
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Effect of OK-432 on proliferation of human mammary cancer cells

ZHANG Rui-shan;LI Xiang;XIE Xian-xin;LI Huan;ZHANG Teng;MA Li-yan;XU Hong;ZHANG Bin;Department of Breast Surgery,Liaoning Cancer Hospital and Institute;  
Objective To observe the effect of OK-432 on the proliferation of MCF-7 cells. Methods The proliferation inhibitory effect of OK-432 on MCF-7 cells was detected by MTT colormetric assay. FAC was used to identify the expression of PC-NA in MCF-7. Results OK-432 obviously inhibited MCF-7 cells proliferation. The proliferation of MCF-7 cells were significantly depressed in the OK-432 combining group( F = 3. 765,P = 0. 000). The ratio of cells in S + G2 / M stage was significantly lower in OK-432 combining group,( 25. 53 ± 1. 77) % vs( 39. 32 ± 2. 56) %( P 0. 05). Conclusion OK-432 significantly inhibits the proliferation of MCF-7 cells.
【Fund】: 国家自然科学基金资助项目(81102029;81172047)
【CateGory Index】: R737.9
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