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《Chinese Journal of Microecology》 2015-01
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The changes of intestinal microbiota affect the expression of brain-derived neurotropic factor in rat hippocampus

CHEN Feng;WANG Long-juan;LI Zhen-zhen;YUAN Xiao-peng;LIU Shuang;FAN Xiao-lei;SUN Wen-chang;Department of Microbiology;Dalian Medical University;Department of Microecology;Dalian Medical University;Department of Occupational and Environmental Health;Dalian Medical University;  
Objective To determine whether the changes of intestinal microbiota could influence the expression of brain-derived neurotropic factor( BDNF) in the hippocampus. Methods Rats were given a mixture of nonabsorbable antimicrobials( ATM,containing neomycin,bacitracin,and natamycin) via drinking water for 7 or 21 days.The bodyweights of rats were recorded. The intestinal microbiota in the feces were detected by using Denaturing Gradient Gel Electrophoresis( DGGE). BDNF expressions in the hippocampus were assessed with Real-time PCR.Results Compared with the control group,there was no significant difference in the bodyweight of the ATM group,however,the intestinal microbiota changed. The expressions of BDNF increased significantly in the hippocampus of ATM rats( P 0. 05). Conclusion The expressions of BDNF in the hippocampus were affected by the changes of intestinal microbiota.
【Fund】: 辽宁省自然科学基金(2014023049);; 大连市科技计划项目(2011E12SF033)
【CateGory Index】: R363
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