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《Chinese Journal of Microecology》 2015-01
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Study on the mechanism of carbapenem-resistant Eshcerichia coli

WU Juan;LI Bin;XU Xiao-hong;PAN Yu-hong;LIU Xiu-qin;WANG Mei-hua;CAO Ying-ping;Department of Clinical Laboratory,Fujian Medical University Union Hospital;Fujian Medical University;  
Objective To investigate the potential mechanism of resistance of carbapenem-resistant E. coli isolates.Methods Carbapenemases were screened by Modified Hodge Test. The Minimum Inhibit Concentration was detected using agar dilution method for 17 drugs. NDM-1,VIM,IMP,KPC-1,SHV,TEM,CTX-M-1 groups and CTXM-9 groups were amplified by PCR and DNA sequencing. Results All of the 21 strains were multi-drug resistance,and all of them were 60% resistant to the eleven drugs which belong to the common seventeen drugs. Moreover the resistant rates of Ceftazidime,Cefotaxime,Ciprofloxacin,Cefoxitin,Aztreonam,were more than 90%.Production of carbapemases was revealed in 9 clinical isolates of carbapenem-resistant E. coli by Modified Hodge Test. The encoding gene of antibiotic-resistant was identified in 18 clinical isolates. 6 of 18 isolates were carbapenem-resistant gene positive that three strains carried NDM-1 gene and three strains carried IMP gene. Conclusion NDM-1 and IMP are the dominant genotypes in these carbapenem-resistant Eshcerichia coli
【Fund】: 福建省科学基金青年项目(2012J05147)
【CateGory Index】: R446.5
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