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《Chinese Journal of Microecology》 2015-01
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Application of Compound Lactobacillus acidophilus Tablets combined with early enteral nutrition in patients with severe craniocerebral injury

FANG Yu-min;ICU,Suichang People's Hospital;  
Objective To discuss the application of Compound Lactobacillus Acidophilus Tablets combined with early enteral nutrition in patients with severe craniocerebral injury. Methods 84 patients with severe craniocerebral injury in ICU were selected and divided into observation group and control group by table of random number,with 42 patients in either group. Both two groups were given routine medical treatments,such as intracranial pressure control,antibiotics,stomach lining protection,brain cells nutrition etc,and enteral nutrition suspension 2000-2500 m L / d at an infusion speed of 100 m L / h. The observation group was additionally given 0. 5 g Compound Lactobacillus acidophilus Tablets,which were ground and melt in warm boiled water and then injected by stomach tube,three times a day for 10 days. The GCS,SOFA and APACHE scores,serum albumin( ALB),hemoglobin( Hb) and intestinal tract s Ig A levels of patients in both groups before and 10 days after the treatment were observed and recorded. Results After 10 days' treatment,the GCS score of patients in both groups increased,however,the SOFA and APACHE scores declined( P 0. 05 or P 0. 01),with the increasing and declining values of patients in observation group much higher than those in control group( P 0. 05). The ALB and Hb levels of patients in both groups declined( P 0. 05 or P 0. 01),with the declining rate in observation group much lower than that in control group( P 0. 05). Meanwhile,the intestinal s Ig A level of patients in observation group obviously rose than before( P 0. 05),while that of patients in control group showed no obvious changes after the treatment( P 0. 05). Conclusion Compound Lactobacillus acidophilus Tablets combined with early enteral nutrition has reliable curative effect on severe craniocerebral injury,which can increase GCS score,decrease SOFA and APACHE scores,slow down the declining rates of ALB and Hb levels,improve the nutritional status,raise the intestinal s Ig A level and enhance local intestinal mucosal immunity.
【CateGory Index】: R651.15
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