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《Chinese Journal of Microecology》 2015-01
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G-CSF-induced graft-versus-leukemia effect in treatment of leukemia relapse after allogeneic hematopoietic stem cell transplantation

YANG Hua;LIU Dong-mei;Department of Hematology,the People's Hospital of Liaoning Province;  
Objective To study the G-CSF-induced graft-versus-leukemia effect after the treatment of allogeneic hematopoietic stem cell transplantation in leukemia relapse. Methods 40 leukemia patients who experienced relapse after allogeneic hematopoietic stem cell transplantation from July 2011 to February 2013 were treated with infusion of G-CSF mobilized peripheral blood mononuclear cells,which included 10 cases of Lymphoblastic leukemia-CR2,16 cases of myeloid leukemia-CR2,4 cases of myeloid leukemia-CR3,6 cases of mixed-cell leukemia,and 4 cases of accelerated phase chronic myeloid leukemia. Within six months after allogeneic hematopoietic stem cell transplantation,all the 40 patients experienced relapse. Then the patients were given G-CSF mobilized peripheral blood mononuclear cells infusions with progressively increased amount of cell,at an interval of 4 weeks.Results 24 patients achieved complete remission again,while 16 patients didn' t. After the infusion,the occurrence of grade I- II acute graft-versus-host disease was seen in 6 cases,chronic graft-versus-host disease in 24 cases,complications didn't occurred in 5 patients. Conclusion Treatment of relapsed leukemia through G-CSF-induced graft-versus-leukemia effect is effective with minor adverse reactions,and be worthy of clinical application
【CateGory Index】: R733.7
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【Co-citations】
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2 Murielle Mimeault;Surinder K Batra;Department of Biochemistry and Molecular Biology, College of Medicine, Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198-5870, United States;;Novel biomarkers and therapeutic targets for optimizing the therapeutic management of melanomas[J];世界临床肿瘤学杂志(英文版);2012-03
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