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《Chinese Journal of Microecology》 2015-10
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Clinical effect of probiotics in the treatment of severe acute pancreatitis

LU Shi-yun;LIN Zhi-hui;PAN Xiu-zhen;Provincial Clinical College of Fujian Medical University;Department of Gastroenterology,Fujian Provincial Hospital;  
Objective To investigate the clinical effect of enteral probiotics in the treatment of severe acute pancreatitis(SAP).Methods A total of 96 patients with SAP admitted in our hospital from July 2013 to December 2014 were randomly divided into Enteral probiotics group(the observation group)and Conventional therapy group(the control group)respectively,48 cases in each group.The hospital stay,time to disappearance of abdominal pain,time to recovery of CRP,time to recovery of serum amylase,infection rate,complication rate and changes of intestinal flora were compared between the two groups.Results After treatment,the time to disappearnce of abdominal pain,time to recovery of CRP,time to recovery of serum amylase as well as the average hospitalization days in the observation group were shorter than those in the control group(P0.05).The incidence rates of infections and complications in both groups decreased significantly(P0.05).The amount of intestinal bifidobacteria and lactobacilli in the observation group improved significantly after the treatment(P0.05).Conclusion Early application of probiotics as adjuvant therapy of SAP can effectively regulate micro-ecological balance of intestinal flora,reduce intestinal mucosal damage,protect the intestinal barrier function,and improve clinical course and prognosis of SAP.
【CateGory Index】: R576
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