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《Chinese Journal of Microecology》 2015-10
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Influence of early enteral nutrition with added probiotics on serum inflammatory factors and intestinal mucous membrane barrier function of patients with severe brain injury

JIANG Ming-ming;FANG Qiang;SUN Qin;XU Wei-hua;HU Xue-zhong;SHAO Tang-hong;ICU,the First Affiliated Hospital of Medical College of Zhejiang Universality;ICU,Cixi People′s Hospital;Clinical Laboratory,Cixi People′s Hospital;  
Objective To discuss the influence of early enteral nutrition with added probiotics on serum inflammatory factors and intestinal mucous membrane barrier function of patients with severe brain injury.Methods 72 patients with severe brain injury were selected and divided into observation group(n=36cases)or control group(n=36cases)at random.Both groups were given the same basic treatment.The patients in control group were additionally given enteral nutrition therapy by early nasogastric tube feeding Peptison enteral nutrition liquid,while the patients in observation group were additionally given 630 mg Bifid Triple Viable Bacteria Enteric Coated Capsules by nasogastric feeding tube.The changes of GCS,serum inflammatory factors including interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α),and gastrointestinal mucosal barrier function indexes D-lactic acid and procalcitonin(PCT)in both groups were observed before and 14 days after the treatment.Results After 14days' treatment,the GCS of patients in both groups obviously rose(P0.05 or P0.01),with the observation group superior to the control group(P0.05).The serum IL-6and TNF-αlevels in both groups obviously declined(P0.05 or P0.01),with the declining rate in observation group much higher than that in control group(P0.05).Meanwhile,the serum Dlactic acid and PCT levels in both groups obviously declined(P0.05 or P0.01),and the declining rate in observation group was much higher than that in control group(P0.05).Conclusion The application of early enteral nutrition with added probiotics as adjunctive therapy(AT)for severe brain injury can raise GCS,down-regulate serum inflammatory factors IL-6and TNF-α,inhibit inflammatory reaction,reduce serum D-lactic acid and PCT markers,protect and repair intestinal mucous membrane barrier and improve gastrointestinal function.
【CateGory Index】: R651.15
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