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《Chinese Journal of Microecology》 2015-10
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The effects of a probiotic in eradication of Helicobacter pylori:A prospective,randomized,double-blind,placebo-controlled study

XIA Chen-mei;CHEN Xia;The First People's Hospital of Wenling;  
Objective To explore the effects of a probiotic Bifid Triple Viable capsules in standard quadruple regime for eradication of H.pylori.Methods 300 patients with H.pylori infection were randomized to the Probiotic group or Placebo group(n=150).The Probiotic group was given the standard quadruple therapy(esomeprazole,clarithromycin,amoxicillin and bismuth)and Bifid Triple Viable capsules,while the Placebo group accepted the same quadruple therapy and placebo;the course of treatment was 14 days.Four weeks after the end of the treatment,13C-breath test was performed.Adverse reactions were recorded during the treatment.Results 287 patients completed the study,145 in Probiotic group and 142 in Placebo group.PP analysis showed the eradication rate was 87.4%in Probiotic group and 76.7%in Placebo group(P0.05),while ITT result showed that the eradication rate was 85.6%in Probiotic group and 75.1%in Placebo group(P0.05).The rate of advise effects in Probiotic group was lower than in Placebo group(P0.05).Conclusion The use of this probiotic combined with standard eradication therapy can improve the eradication rate of H.pylori and reduce the rate of adverse effects.
【CateGory Index】: R57
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