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《Chinese Journal of Microecology》 2015-10
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Resistance of Staphylococcus aureus in advanced lung cancer patients with lower respiratory tract infection

WANG Xiao-juan;CHEN Jun-hua;WANG Hui-jiao;Clinical Laboratory Department of Zhejiang Jinhua People′s Hospital;Clinical Laboratory Department of Jinhua Wenrong Hospital;  
Objective To learn the clinical characteristics and resistance of Staphylococcus aureus(SA)from lower respiratory tract infections in patients with advanced lung cancer,and provide reference for rational use of drugs.Methods Clinical specimens of advanced lung cancer patients with lower respiratory tract infections admitted in Zhejiang Jinhua People's Hospital from December 2009 to November 2014 were collected.BioMérieux Vitek 2-Compact was used to identify the bacteria.Drug susceptibility was tested by using disk method(K-B).Results In the total of 157 strains of SA,98strains(62.4%)were methicillin-resistant Staphylococcus aureus(MRSA).The resistance rates of the MRSA strains were 100.0%to Penicillin G,Erythromycin,Tetracycline,Cefoxitin and Moxifloxacin,while those toβ-lactams,Quinolones,Macrolides,Aminoglycosides and Sulfonamides ranged between 26.5% and 93.9%.There were multi-drug resistant MRSAs with the resistance rate significantly higher than that of MSSAs(P0.05).Conclusion MRSAs are the main pathogens isolated from advanced lung cancer patients with lower respiratory tract infections,which have higher resistance than MSSAs,and many are multi-drug resistant.The monitoring of Staphylococcus aureus infection should be enhanced,and drugs should be used rationally based on susceptibility test results.
【CateGory Index】: R446.5;R734.2
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