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《Chinese Journal of Microecology》 2015-10
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The vaginal microecosystem in cervical cancer patients with persistent HPV infection after cervical cancer surgery

WU Qiu-ping;YE Jin-yan;CHENG Hao;LIU Xia;JIANG Yan-ying;Maternal and Child Health Hospital of Jiaxing;Sir Run Shaw Hospital of Zhejiang;  
Objective To discuss the pathogenic characteristics and provide evidence for recovery of vaginal microecological balance and HPV treatment through analyzing the vaginal microecosystem in cervical cancer patients with persistent post-operative HPV infection.Methods 75 cervical cancer patients with persistent post-operative HPV infection were included,with 50 healthy postmenopausal women as the controls;their vaginal secretion specimens were dtected.Results The rate of vaginal microecosystem imbalance in Patient group was 72.0%;dominant bacteria accounted for 50.7%;46.7% of patients showed levelⅡ-Ⅲ of bacteria concentration;42.7% showed levelⅡ-Ⅲ of bacteria diversity;pH≤4.5accounting for 28.0%;all of which were significantly different compared with the control group(P0.05).In patients not elder than55 years,the dominant bacteria accounted for 59.1%,significantly different from that in patients elder than55years(P0.05);No significant differences were found in bacteria concentration,bacterial diversity,pH value,vaginal microecological imbalance,VVC and BV.Conclusion(1)Vaginal microecosystem imbalance exists in Patient group.(2)The dominant bacteria in the vagina of patients55years showed obvious differences.(3)Evaluation of vaginal microecosystem for persistent post-operative HPV infection in patients with cervical cancer has important guiding significance for recovery of vaginal microecological balance and HPV treatment.
【Fund】: 嘉兴市科技计划项目(2013AY21050-3)
【CateGory Index】: R737.33
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