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《Chinese Journal of Microecology》 2015-12
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The triterpenoids from medicinal macrofungi Ganodermalucidum

HUANG Shan-shan;DENG Sa;ZHANG Hou-li;ZHANG Bao-jing;HUO Xiao-kui;MA Xiao-chi;WANG Chao;College of Pharmacy,Dalian Medical University;  
Objective To study the bioactivity and structure of the triterpenoids in Ganodermalucidum(Polyporaceae).Methods The ethanolic extracts of Ganodermalucidum was diluted with water and extracted with CHCl_3.The CHCl_3 extract was subjected to silica gel column chromatography and HPLC successively.The structures of isolated compounds were identified by using various spectroscopic techiques,including UV,ESI-MS,HRESI-MS,~1H-NMR,~(13)C-NMR and 2D-NMR.Theα-Glucosidase inhibitory activity of the extracted compounds were evaluated in vitro.Results 7lanostane triterpenoids(Compound 1to 7)were isolated from the fruiting body of Ganodermalucidum,which were identified as Ganoderic acid X1(Compound 1),Ganoderic acid C(Compound 2),Deacetyl-Ganoderic acid F(Compound 3),Ganoderic B(Compound 4),Lucienic acid A(Compound 5),7-hydroxy-3,11,15-trioxo-lanosta-8-en-24→20sLactone(Compound 6)and Methyl lucidenate D2(Compound 7).An in vitro bioassay showed that the compounds 1and 6have certainα-Glucosidase inhibitory activities.Conclusion Lanostane triterpenoids are the major ingredients of Ganodermalucidum.Ganoderic acid X1 is a new triterpenoid not reported before.These chemical ingredients have certain bioactivities.
【Fund】: 辽宁省教育厅一般研究项目(L2014352)
【CateGory Index】: R284
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