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《Chinese Journal of Microecology》 2017-08
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Progress in research on the cag pathogenicity island encoded type Ⅳ secretion system of Helicobacter pylori

CHANG Aiying;DING Shuyan;CONG Peixia;Department of Central Lab,Weihai Municipal Hospital;  
Many Gram-negative pathogens harbor type Ⅳ secretion systems(T4SSs)which can transfer bacterial biological macromolecules or virulence factors into host cells to play corresponding roles.The chromosomes of H.pylori have been found so far to be able to encode up to three T4SSs,among which cagPAI has been well studied for its role in chronic H.pylori infection.In addition,the comBand tfs3 system encoded by the plastic zone are also reported.The T4SS of H.pylori,as an important structure related to disease,has been concerned by many scholars in the world.The study on T4SS system of H.pylori will be helpful to clarify the pathogenic mechanism,and provide a new target for clinical diagnosis and treatment of gastroduodenal diseases.Here,we reviewed our knowledge about the T4SS system in H.pylori and its role in pathogenesis.
【Fund】: 山东省自然科学基金(ZR2015HM072;ZR2016HM63)
【CateGory Index】: R378
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