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THE EXPERIMENTAL STUDY OF FLUOROQUINOLONES RESISTANT STRAINS IN GRAM NEGATIVE BACILLI

Lin Jianmei Fan Xinjian FenPing,et al. Department of Infectioas Diseases,West China University of Medical Sciences,Chengdu 610041  
A study was taken to evaluate the susceptibility patterns of Gram negative bacilli(82 Strains) isolated from patients. All of the strains,which include E. coli(65 strains),P.aeruginosa(7 strains), E. cloacal(4 strains).Ac. anitratum(3 strains),P.vulgaris(l strain),K.Pneurmoniae (1 strain), and A. faecalis (1 strain),were studied for suscepitibility to five kinds of fluoroquinolones(FQNS), ampicillin (Amp), gentamycin(GM), amikacin(AMK), cefoperazone(CPZ),cefazilin (CEZ),imipenem(IMP) by a tube dilution method,The result showed that the rates of resistance to norloxacin (NFLX) was 97.5%, enoxacin(ENX) 96.34%,lomefloxacin (LMLX) 95.2%, ofloxacin(OFLX) 92.68%,and ciprofloxacin(CPLX) 87.8%,respectively.Cross-resistances to five kinds of FQNS exist extensively.Plasmid profile showed that 43 strains include plasmids (52.44%) and no FQNS resistant plasmid was detected.
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