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《Chinese Journal of Public Health Engineering》 2016-01
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Toxicity of a new type of composite hand washing liquid containing chlorhexidine acetate

ZHAO Yi-hui;ZHANG Jing-ying;SUN Lan;SONG Xin-tian;MENG Ling-yi;Sample Received Section,Jilin Provincial Center for Disease Control and Prevention;  
Objective To understand the safety of the compound liquid soap of chlorhexidine acetate. Methods Acute toxicity,bone marrow micronucleus,skin irritation and subacute toxicity test were carried out by using different kinds of experimental animals. Results The compound hand washing liquid of chlorhexidine acetate,the acute oral LD50 in mice was more than 5 000 mg / kg. The hand sanitizer induced bone marrow micronucleus; the rabbit dermal no stimulation index was0; subacute toxicity test,general physical signs no abnormal,on rat body weight,blood routine test,blood biochemistry,dirty body coefficient and histopathological examination showed no abnormalities were found,in the 62. 5-1 000 mg / kg dose range did not observe to toxic effects. Conclusion The disinfection liquid is practically non-toxic and has no effect on the micronucleus,and has no irritation to skin.
【CateGory Index】: R187
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