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《China Pharmacy》 2008-01
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Studies on the Recognition-behaviors of Molecularly Imprinted Polymerintroduced β-cyclodextrin towards β-blocked Reagents

HE Jian-feng(College of Chinese Traditional Medicine,Guangzhou University of Chinese Medicine,Guangzhou 510006,China)XU Li(Dept.of Chemistry,South China Agricultural University,Guangzhou 510642,China)ZHU Quan-hong(School of Chinese Traditional Medicine,Southern Medical University,Guangzhou 510515,China)  
OBJECTIVE:To explore the preparation methods of drug-molecularly imprinted polymer in aqueous phase and the substrate-recognition behaviors of the polymers.METHODS:The β-blocked reagents carvedilol and metoprolol molecularly imprinted polymers were successfully synthesized in aqueous phase by utilizing the polymerisable β-cyclodextrin as functional monomer,N,N-methylene-bisacrylamide as crosslinker,respectively.The affinity and selectivity of imprinted polymers for the templates and its structural analogues were evaluated in acetonitrile-water solvent by equilibrium binding experiments.RESULTS:The carvedilol and metoprolol molecularly imprinted polymers exhibited higher substrate-selectivity and recognition ability toward template,and the adsorption behaviors of the imprinted polymers were same as the "key-lock"relation between the enzyme and the substrate,however,the blank polymer didn't.CONCLUSIONS:The studies provided a feasible way to prepare molecularly imprinted polymers for drugs molecules in aqueous phase with highly recognizing ability.
【Key Words】： Molecularly imprinted polymer β-cyclodextrin Carvedilol Metoprolol
【Fund】： 国家自然科学基金资助项目(30300445);; 广州中医药大学创新基金资助项目(K0050035)
【CateGory Index】： R94
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【Co-citations】
Chinese Journal Full-text Database 5 Hits
1 XIE Zhen-ming 1,HE Jian-feng 2,YU Lin 1,PAN Jian-ming 1(1.Guangdong University of Technology,Faculty of Chemical Engineering and Light Industry,Guangzhou 510006,China; 2.School of Chinese Materia Medica,Guangzhou University of Chinese Medicine,,Guangzhou 510006,China);Preparation of Oridonin molecularly imprinted polymers and study on its molecular recognition properties[J];Chemical Research and Application;2011-10
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4 HE Jianfeng XU Li ZHU Quanhong(College of Chinese Medicine,Guangzhou University of Chinese Traditional Medicine,Guangzhou 510006,China)(Dept. of Chemistry,South China Agricultural University,Guangzhou 510642,China)(School of Chinese Traditional Medicine,Southern Medical University,Guangzhou 510515,China);Preparation and Binding Characteristic of the Precursor of Chloramphenicol Imprinted Polymers[J];China Pharmacy;2007-22
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